1997
DOI: 10.1021/bk-1998-0682.ch006
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Structure and Stability of DNA Containing Inverted Anomeric Centers and Polarity Reversals

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Cited by 6 publications
(8 citation statements)
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“…A reduction in thermostability due to this modification is in agreement with the demonstrated disruptive effect of an a-nucleotide within a self-complementary sequence. 26 Moreover, on the basis of DG, a DNA nonamer duplex featuring the same aA modification but flanked by purines, was found to be slightly less stable than the control duplex containing a normal bA·T base-pair. 25 However, the difference in stability between the control and alphaA duplexes was much smaller in that case, which may be attributed to differing flanking sequences.…”
Section: Endonuclease IV Reactivitymentioning
confidence: 99%
“…A reduction in thermostability due to this modification is in agreement with the demonstrated disruptive effect of an a-nucleotide within a self-complementary sequence. 26 Moreover, on the basis of DG, a DNA nonamer duplex featuring the same aA modification but flanked by purines, was found to be slightly less stable than the control duplex containing a normal bA·T base-pair. 25 However, the difference in stability between the control and alphaA duplexes was much smaller in that case, which may be attributed to differing flanking sequences.…”
Section: Endonuclease IV Reactivitymentioning
confidence: 99%
“…[27] This notion was supported by previous work since a single 3'-5' linked α-anomeric thymidine generate a new class of ODNs. [25] The 3'-3' and 5'-5' linkages allow the local inversion of the strand polarity, enabling the parallel stranded α-anomeric tracts to form Watson-Crick base pairs with the RNA target.…”
Section: Alpha Anomeric Damage and Recognitionmentioning
confidence: 77%
“…[25] The 3'-3' and 5'-5' linkages allow the local inversion of the strand polarity, enabling the parallel stranded α-anomeric tracts to form Watson-Crick base pairs with the RNA target. This results in ODNs that permit RNase H to destroy the RNA component of an ODN•RNA heteroduplex [26][27][28] and selectively inhibit growth in two cervical carcinoma cell lines as well as in tumor-bearing mice. [29] These ODNs bind more strongly to the target RNA than phosphorothioates due to the enantiomeric purity of α-anomeric nucleotides and the inherent stability of α-ODN/β-RNA hybrids.…”
Section: Alpha Anomeric Damage and Recognitionmentioning
confidence: 99%
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“…2A). 77,117 This lesion is produced under anaerobic conditions by hydroxyl radicals, and is a major lesion produced by g-irradiation under anoxic conditions is an a-adenosine (aA) lesion. 77 The altered nucleotide is mutagenic because it directs the incorporation of C, A, and T in vitro and generates deletions in vivo.…”
Section: Abasic Site Recognitionmentioning
confidence: 99%