Structure and Stability of Triglyceride Monolayers on Water and Mica Surfaces

Zdravkova, Aneliya N.; Eerden, J.P.J.M. van der

doi:10.1021/cg060701t

Cited by 10 publications

(22 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like in monocomponent systems [22,23] we found higher domains on top of the PPP-SSS monolayer. Most of them had a thickness of 3.570.1 nm (Figs.…”

Section: Article In Presssupporting

confidence: 72%

“…In this mode we chose barrier velocities of the order of 1 cm/min, which according to the literature should be slow enough that the Langmuir film stays close to thermodynamic equilibrium. It should be mentioned however, that in previous work [23] we have shown that, for condensed phases this compression rate is still too high for the film to be in equilibrium.…”

Section: Langmuir Methodsmentioning

confidence: 70%

“…In previous work [23] we already discussed the shape of the typical pÀA isotherms of PPP, SSS and AAA, where two different regimes can be recognized for the three triglycerides. The condensation area A cond and condensation pressure p cond have been described as values indicating the transfer from ''gaseous'' to ''condensed'' phase.…”

Section: Langmuir Observationsmentioning

confidence: 99%

“…To measure the real monolayer thickness d 0 of the mixture PPP-SSS (1:1) we used the same procedure as in Ref. [23]. By scanning with a relatively large force FE30 nN we scratched a rectangular hole in the monolayer with the AFM tip.…”

Section: Ppp-sss Structurementioning

confidence: 99%

“…Using AFM the thickness of the trident monolayers was measured. It is 1.49 nm for PPP, 1.75 nm for SSS and 2.2 nm for AAA, corresponding to tilt angles of the molecules of 461, 491 and 591, respectively [23].…”

Section: Introductionmentioning

confidence: 98%

See 4 more Smart Citations

Phase behaviour in binary mixed Langmuir–Blodgett monolayers of triglycerides

Zdravkova

Eerden

2007

Journal of Crystal Growth

Self Cite

View full text Add to dashboard Cite

Binary mixed monolayers of the triglycerides (TAGs)-tripalmitin (PPP), tristearin (SSS) and triarachidin (AAA) at the air-water interface are investigated with the Langmuir method. Langmuir-Blodgett (LB) layers obtained by deposition on mica are investigated by Atomic Force Microscopy. Combining Langmuir and AFM results the relation between the phase behaviour of binary mixed TAGs and their chain length is established. TAG mixtures form monolayers with molecules in trident conformation at the air-water interface, like pure TAGs. The area A cond ¼ 63 Å 2 and the pressure p cond ¼ 8-10 mN/m that separate ''gas'' and ''condensed'' film structures are the same for all mixtures and pure systems. In the pÀA isotherms the sharpness of the transition from ''gas'' to ''condensed'' phase decreases with the average chain length for all systems. Using AFM data the monolayer thicknesses for mixtures and pure systems is found to be linearly dependent on the average chain length of the TAG molecules. A linear relation between film thickness and applied AFM force is established. The corresponding coefficientK is higher for mixed monolayers (K ¼ 0:08 AE 0:01 nN À1 ) than for pure systems (K ¼ 0:07 AE 0:01 nN À1 ). AFM images show phase separation in the systems PPP-SSS and PPP-AAA. The solubility of the shorter PPP molecules in the ''long'' (SSS-and AAA-rich) phase is significant. For the mixture SSS-AAA, phase separation is not observed. In that mixture the monolayer thickness varies linearly with composition, supporting the conclusion that SSS and AAA mix almost ideally. The main driving force for phase separation is the difference in the alkyl chain length. Indeed PPP-AAA (length difference 4 C atoms) shows the most clear phase separation. The relatively weak phase separation in PPP-SSS and the absence of phase separation in SSS-AAA show that the influence of chain length difference decreases with increasing average chain length. In air PPP-SSS and PPP-AAA mixed monolayers are unstable and crystals with a-and b-like structure are formed on top of the monolayer as in pure PPP and SSS systems. r

show abstract

“…Like in monocomponent systems [22,23] we found higher domains on top of the PPP-SSS monolayer. Most of them had a thickness of 3.570.1 nm (Figs.…”

Section: Article In Presssupporting

confidence: 72%

Section: Langmuir Methodsmentioning

confidence: 70%

Section: Langmuir Observationsmentioning

confidence: 99%

Section: Ppp-sss Structurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

See 3 more Smart Citations

Phase behaviour in binary mixed Langmuir–Blodgett monolayers of triglycerides

Zdravkova

Eerden

2007

Journal of Crystal Growth

Self Cite

View full text Add to dashboard Cite

show abstract

Physicochemical Characterization of Chrysin‐Derivative‐Loaded Nanostructured Lipid Carriers with Special Reference to Anticancer Activity

Karmakar

Nahak

Chettri

et al. 2018

J Surfact & Detergents

View full text Add to dashboard Cite

Homologues long‐chain chrysin derivatives (LCD, C n: 8–18) were synthesized and incorporated into nanostructured lipid carriers (NLC) with the aim to treat human neuroblastoma. Mutual miscibility and attractive interactions among the NLC components, namely tripalmitin (TP), cetyl palmitate (CP), oleic acid (OA), and the chrysin (CHR) derivatives (LCD) at the air–water interface were assessed by the Langmuir monolayer approach. Optimum combination for the NLC formulations was found to be 2:2:1 (M/M/M) for TP/CP/OA, respectively. NLC formulations, both in the absence and presence of LCD, were characterized by combined dynamic light scattering, electron microscopy, atomic force microscopy, and differential scanning calorimetry. The size and zeta potential of the NLC formulations were found in the range 200–350 nm and −12 to −18 mV, respectively. Encapsulation efficiency and release kinetics of CHR and LCD when loaded into NLC were also evaluated. LCD exhibited maximum incorporation, drug‐loading capacity, and sustained release because of its enhanced hydrophobicity. Superior incorporation efficiency and sustained‐release profile of LCD were able to enhance their anticancer activity against human neuroblastoma cell lines, compared to CHR, making them promising agents in combating cancer.

show abstract

Polymorphic phase transitions in triglycerides and their mixtures studied by SAXS/WAXS techniques: In bulk and in emulsions

Cholakova,

Denkov

2024

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

Structure and Stability of Triglyceride Monolayers on Water and Mica Surfaces

Cited by 10 publications

References 19 publications

Phase behaviour in binary mixed Langmuir–Blodgett monolayers of triglycerides

Phase behaviour in binary mixed Langmuir–Blodgett monolayers of triglycerides

Physicochemical Characterization of Chrysin‐Derivative‐Loaded Nanostructured Lipid Carriers with Special Reference to Anticancer Activity

Polymorphic phase transitions in triglycerides and their mixtures studied by SAXS/WAXS techniques: In bulk and in emulsions

Contact Info

Product

Resources

About