Structure and synthesis of atalaphylline and related alkaloids

Alkaloids from Oriciopsis glaberrima Engl. (Rutaceae)☆

“…This finding clearly indicated that the hydroxydimethylchroman ring was fused in an angular fashion. All this information is in agreement with the acridone skeleton (Bahar et al, 1982;Magiatis et al, 2001). The presence of an acridone skeleton was also confirmed by the EI MS mass spectrum, which showed a peak at m/z 311 (C 18 H 16 NO 4 ).…”

Quinoline, quinazoline and acridonealkaloids

“…106 Compound 281, although a new natural product, has previously been synthesised. 109 The final new alkaloid, (+)-oriciacridone F 282, is a more conventional bisacridone involving dimerisation of two 5-hydroxy-N-desmethylnoracronycine units 276. The new alkaloids 273, 281 and 282 were reasonably effective inhibitors of Saccharomyces a-glucosidase at concentrations of 100 lM or less, while the same three alkaloids as well as 274 exhibited moderate radical scavenging ability towards 1,1-diphenyl-2-picrylhydrazyl, which implies some antioxidant activity.…”

.ALPHA.-Glucosidase Inhibitory and Antioxidant Acridone Alkaloids from the Stem Bark of Oriciopsis glaberrima ENGL. (Rutaceae)

“…We also present the 13 C values and biological activity of synthetically known acridone 1,3,5-trihydroxy-4-prenylacridone. 5) Air-dried, ground stem bark of O. glaberrima was extracted with a mixture of CH 2 Cl 2 -MeOH (1/1) at room temperature. The extract was concentrated to dryness under vacuum and its antioxidant activity was evaluated.…”