Structure–antimicrobial activity relationship for silanols, a new class of disinfectants, compared with alcohols and phenols

Kim, Yunmi; Farrah, Samuel R.; Baney, Ronald H.

doi:10.1016/j.ijantimicag.2006.08.036

Cited by 92 publications

(57 citation statements)

References 15 publications

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“…Here the hydrophobicity of the molecules increased gradually from compound 4 to 9. The hydrophobicity of materials is an important parameter with respect to such bioactivity as toxicity or alteration of membrane integrity, because it is directly related to membrane permeation [36]. Hunt [37] also proposed that the potency of aliphatic alcohols is directly related to their lipid solubility through the hydrophobic interaction between alkyl chains from alcohols and lipid regions in the membrane.…”

Section: Antibacterial Activitiesmentioning

confidence: 99%

Chemically Modified Uridine Molecules Incorporating Acyl Residues to Enhance Antibacterial and Cytotoxic Activities

Kawsar¹,

Ara²,

Uddin³

et al. 2015

IJOC

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A new N-acetylsulfanilylation series of uridine have been synthesized in good yield using direct acylation method and afforded the 5'-O-N-acetylsulfanilyluridine. In order to obtain newer products, the 5'-O-N-acetylsulfanilyluridine derivative was further transformed to a series of 2',3'-di-Oacyl derivatives containing a wide variety of functionalities in a single molecular framework. The chemical structures of the newly synthesized compounds were confirmed on the basis of their FTIR, 1 H-NMR spectroscopy, physicochemical properties and elemental analysis. All the synthesized uridine derivatives were tested for their in vitro antibacterial activity against six human pathogenic bacterial strains and for comparison standard antibiotic Ampicillin was also determined. The study revealed that the selectively acylated derivatives 5'-O-N-acetylsulfanilyl-2',3'-di-O-lauroyluridine and 5'-O-N-acetylsulfanilyl-2',3'-di-O-pivaloyluridine showed highest inhibition against Staphylococcus aureus and Bacillus cereus, respectively. We also observed that the introduction of hexanoyl, decanoyl, lauroyl, myristoyl and pivaloyl groups, the antibacterial functionality of the compound uridine increases. Another noteworthy observation was that the uridine derivatives * Corresponding author. S. M. A. Kawsar et al. 233were found comparatively more effective against Gram-positive microorganisms than those of Gram-negative microorganisms. In addition, the test chemicals were also tested for cytotoxicity by brine shrimp lethality bioassay and compounds showed different rate mortality with different concentrations.

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Section: Antibacterial Activitiesmentioning

confidence: 99%

Chemically Modified Uridine Molecules Incorporating Acyl Residues to Enhance Antibacterial and Cytotoxic Activities

Kawsar¹,

Ara²,

Uddin³

et al. 2015

IJOC

View full text Add to dashboard Cite

show abstract

“…The hydrophobicity of compounds is an important parameter for bioactivity such as toxicity or alteration of membrane integrity, and is directly related to membrane permeation. 33 Hunt 34 proposed that the antimicrobial activities of alcoholic compounds is directly related to their lipid solubility through the hydrophobic interaction between alkyl chains of alcohols and lipid regions in the membrane. A similar hydrophobic interaction might occur between the acyl chains of glucofuranoses accumulated in the lipid like nature of the bacteria membranes.…”

Section: Structure Activity Relationship (Sar)mentioning

confidence: 99%

“…As a consequence of their hydrophobic interaction, bacteria lose their membrane permeability, ultimately causing death of the organism. [33][34][35] It was observed from Table 2 and Table 3 that 4-O-lauroyl-2,3-di-O-acetate/mesylate/benzoate (8/9/10) exhibited excellent activity against both bacterial and fungal pathogens which were, in some cases, comparable to that of the standard antibiotic. This led us to conclude that incorporation of 4-Olauroyl group in rhamnopyranoside frame work along with 2,3-di-O-acetyl/mesyl/benzoyl group increased the antimicrobial potentiality of the rhamnopyranoside 4.…”

Section: Structure Activity Relationship (Sar)mentioning

confidence: 99%

Design and synthesis of benzyl 4-O-lauroyl-α-L-rhamnopyranoside derivatives as antimicrobial agents

Matin¹,

Bhuiyan²,

Azad³

et al. 2017

10.5267/j.ccl

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“…They include chemotherapy, immunization, sterilization and disinfection (Kim, et al, 2007). Subsequently, decontamination, disinfection and sterilization became main components of any infection control program (Rutala, et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Synergistic and/or Antagonistic Studies of Norfloxacin with Some Disinfectants Against Salmonella Enteritidis

Mansour¹,

Ibrahim²,

Shaheen³

2018

AJVS

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Key words: SalmonellaEnteritidis, Disinfectants, TH4,Virkon-S, Povidone Iodine, Norfloxacin Salmonella enterica serovar Enteriditis (S.Enteritidis) is a food borne pathogen of human causing food-poisoning and sometime deaths. Many methods have been carried out to decrease the population and prevalence of the causative agent, including chemotherapy and disinfection. In this study, in vitro combination between chemotherapy and disinfection was carried out. Three disinfectants [TH4® (combination of quaternary ammonium compound and gluteraldhyde), Povidone Iodine®(iodophore) and Virkon® S(peroxygen compound)] were tested in vitro against S.Enteritidis. The effect of disinfectants, concentration and time of exposure on the survival of S.Enteritidis was investigated.TH4 0.5% (w/v), Virkon S 1% (w/v) and Povidone iodine7.5%(w/v) reduced S. Enteritidis by 99.9%,72% and 87%, respectively. Further, as the disinfectants' concentration decreased, the survival of bacteria increased. Virkon S and Povidone Iodine recorded satisfied result at 10 min exposure time. TH4 recorded high results at 30 min exposure time. The in vitro combination between the three disinfectants and Norfloxacin 10% showed improvement of the inhibitory effect of TH4 and Povidone Iodine, while the inhibitory effect of Virkon S decreased. In addition, formation of macroscopically white precipitation, which interfere with effect of the two (Virkon S and norfloxacin 10%) and lead to bad inhibitory effect on S. Enteritidis.

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Structure–antimicrobial activity relationship for silanols, a new class of disinfectants, compared with alcohols and phenols

Cited by 92 publications

References 15 publications

Chemically Modified Uridine Molecules Incorporating Acyl Residues to Enhance Antibacterial and Cytotoxic Activities

Chemically Modified Uridine Molecules Incorporating Acyl Residues to Enhance Antibacterial and Cytotoxic Activities

Design and synthesis of benzyl 4-O-lauroyl-α-L-rhamnopyranoside derivatives as antimicrobial agents

In Vitro Synergistic and/or Antagonistic Studies of Norfloxacin with Some Disinfectants Against Salmonella Enteritidis

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