2014
DOI: 10.1021/ja509648u
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Structure-Based Design of Functional Amyloid Materials

Abstract: Amyloid fibers, once exclusively associated with disease, are acquiring utility as a class of biological nanomaterials.Here we introduce a method that utilizes the atomic structures of amyloid peptides, to design materials with versatile applications. As a model application, we designed amyloid fibers capable of capturing carbon dioxide from flue gas, to address the global problem of excess anthropogenic carbon dioxide. By measuring dynamic separation of carbon dioxide from nitrogen, we show that fibers with d… Show more

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Cited by 104 publications
(91 citation statements)
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“…To enrich the class of amyloid-like nanosheets, we attempted to design the nanosheet from scratch. According to the structure of the KLVFFAK nanosheet, a nanosheet-forming peptide should contain the properties of fibril-forming peptides (36)(37)(38) and additionally be able to stack along the zippering axis, as shown in Fig. 2A, through face to face or face to back patterns.…”
Section: Significancementioning
confidence: 99%
“…To enrich the class of amyloid-like nanosheets, we attempted to design the nanosheet from scratch. According to the structure of the KLVFFAK nanosheet, a nanosheet-forming peptide should contain the properties of fibril-forming peptides (36)(37)(38) and additionally be able to stack along the zippering axis, as shown in Fig. 2A, through face to face or face to back patterns.…”
Section: Significancementioning
confidence: 99%
“…Based on a generic set of genetic engineering procedures, recombinant protein production has largely impacted on biotechnological and biopharmaceutical industries, with more than 400 protein drugs approved for human use [1]. The identification [2,3] and exploitation [4,5] of oligomerization domains, the tailored fibrillation of amyloidal protein forms [6] and the de novo design of protein-protein interacting patches [7,8] offer a wide spectrum of possibilities regarding the generation of supramolecular materials to be used in biological interfaces [9][10][11]. Being functional but also biocompatible and biodegradable, protein materials show a still unexplored biomedical potential in both regenerative medicine and conventional or cell-targeted drug delivery [12,13].…”
Section: Introductionmentioning
confidence: 99%
“…[58][59][60][61][62] To some extent, peptide seems to be the appropriate candidate to improve the hydrophilicity and broaden the biomedical applications of carbon materials. 4,63,64 Take G or graphene oxide (GO) for an example, although they have relatively good mechanical properties and biocompatibility, the hybridization of graphene with peptide can further reinforce these advantages and provide the possibility for detecting biomolecules.…”
Section: 22mentioning
confidence: 99%