Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP

Kuo, Wen-Chih; Lee, Cheng-Chung; Chang, Ya-Wen; Pang, Wei Wei; Chen, Hong-Sen; Hou, Shin-Chen; Lo, Shin-Yi; Yang, An-Suei; Wang, Andrew H.‐J.

doi:10.1016/j.jmb.2020.166766

Cited by 11 publications

(13 citation statements)

References 43 publications

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“…The signaling pathways, such as JNK and NF-kappa B, were also involved in the development of insulin resistance ( Matulewicz and Karczewska-Kupczewska, 2016 ; Solinas and Becattini, 2017 ; Bako et al, 2019 ). IL-1β is regulated by the IL-1RI/NF-κB pathway and is a tumor-related factor leading to MDSC amplification and migration ( Cervantes-Villagrana et al, 2020 ; Kuo et al, 2021 ). Previous studies showed a positive correlation between IL-1β and MDSC frequency in 4T1 breast cancer, lung cancer, advanced melanoma and other tumors ( Bunt et al, 2006 ; Shi et al, 2017 ; Cervantes-Villagrana et al, 2020 ).…”

Section: The Recruitment Of Mdsc In the Development Of Diabetesmentioning

confidence: 99%

Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

et al. 2021

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Diabetes is a syndrome characterized by hyperglycemia with or without insulin resistance. Its etiology is attributed to the combined action of genes, environment and immune cells. Myeloid-derived suppressor cell (MDSC) is a heterogeneous population of immature cells with immunosuppressive ability. In recent years, different studies have debated the quantity, activity changes and roles of MDSC in the diabetic microenvironment. However, the emerging roles of MDSC have not been fully documented with regard to their interactions with diabetes. Here, the manifestations of MDSC and their subsets are reviewed with regard to the incidence of diabetes and diabetic complications. The possible drugs targeting MDSC are discussed with regard to their potential of treating diabetes. We believe that understanding MDSC will offer opportunities to explain pathological characteristics of different diabetes. MDSC also will be used for personalized immunotherapy of diabetes.

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Section: The Recruitment Of Mdsc In the Development Of Diabetesmentioning

confidence: 99%

Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

et al. 2021

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“…The high-resolution crystal structures of the RBD of the spike proteins of the SARS-CoV-2 wild-type (PDB ID: 6M0J Chain B) 3 and the SARS-CoV-2 variant P.1 (PDB ID: 7NXC Chain B) 15 were downloaded from PDB (http://www.rcsb.org). Crystal structures of the human ACE2 receptor (PDB ID: 6M0J Chain A), 3 serine protease TMPRSS2 (PDB ID: 7MEQ Chain A), 16 cysteine protease CTSL (PDB ID: 6EZP Chain A), 17 endocytic regulator AAK1 (PDB ID: 4WSQ Chain A), 18 and the proinflammatory cytokines-IL-6 (PDB ID: 1ALU Chain A), 19 IL-1β (PDB ID: 7CHY Chain C), 20 TNF-α (PDB ID: 2AZ5…”

Section: Retrieval and Refinement Of The Protein Structuresmentioning

confidence: 99%

“…26 Detailed information regarding the grid box co-ordinates of the active interaction/inhibition pockets (binding pockets) of the protein structures was obtained from existing literature. [18][19][20][21][22]27 Protein-ligand interaction profiler webserver 28 was used for studying molecular interactions.…”

Section: Molecular Dockingmentioning

confidence: 99%

“…Cynaroside interacted with the residues Asn123, Val157, Lys179, and Glu180 at the active binding pocket of IL-1β (Table 3 and Figure 5B). 20 A previous study reported that cynaroside exerts beneficial anti-inflammatory activity in mice by downregulating the release of proinflammatory cytokines from T cells and mast cells. The proinflammatory cytokines TNF-α and IFN-γ lead to the activation of Janus kinase/signal transducer and activator of transcription pathway and trigger the generation of nitric oxide associated with oxidative stress and damage.…”

Section: Interaction Of the Phytocompounds With The Host Proteins Ass...mentioning

confidence: 99%

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Computational profiling of natural compounds as promising inhibitors against the spike proteins of SARS‐CoV‐2 wild‐type and the variants of concern, viral cell‐entry process, and cytokine storm in COVID‐19

Kar

Saleh‐E‐In

Jaishee

et al. 2022

J of Cellular Biochemistry

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The continuous spread and evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and the rapid surge in infection cases in the coronavirus disease 2019 (COVID-19) evoke a dire need for effective therapeutics. In this study, we explored the inhibitory potential of a library of 605 phytocompounds, selected from Indian medicinal plants with reported antiviral and anti-inflammatory activities, against the receptor-binding domain of spike proteins of the SARS-CoV-2 wild-type and the variants of concern, including variants B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma), B.1.617.2 (Delta), and B.1.1.529 (Omicron). Our approach was based on extensive molecular docking, assessment of drug-likeness, and robust molecular dynamics simulations. We also identified promising inhibitory candidates against the host (human) proteins associated with SARS-CoV-2

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“…The IL-1β structure including an α-helix, β-sheets and loops (shown in violet color) (PDB ID 7CHZ) [38].…”

Section: Figurementioning

confidence: 99%

A World of Wonders: Interleukin-1 (IL-1) and IL-2 Families

Gajdács¹,

García‐Perdomo²,

Sarshar³

et al. 2021

Interleukins - The Immune and Non-Immune Systems’ Related Cytokines

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Human interleukins (ILs) are a collection of different biological molecules belonging to the group of cytokines, associated with various immune and non-immune systems and different signaling pathways. ILs contribute to the function of different tissues, organs and systems in the human body. They are involved in homeostasis, infectious diseases, autoimmune diseases, cancers and even therapeutics. Due to this knowledge, this chapter aims to summarize the importance of the IL-1 and IL-2 superfamilies.

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Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP

Cited by 11 publications

References 43 publications

Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

Emerging Roles of Myeloid-Derived Suppressor Cells in Diabetes

Computational profiling of natural compounds as promising inhibitors against the spike proteins of SARS‐CoV‐2 wild‐type and the variants of concern, viral cell‐entry process, and cytokine storm in COVID‐19

A World of Wonders: Interleukin-1 (IL-1) and IL-2 Families

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