Structure-Based Gastro-Retentive and Controlled-Release Drug Delivery with Novel 3D Printing

Wen, Haoyang; He, Bin; Wang, Haoyu; Chen, Fen; Li, Pingfei; Cui, Mengsuo; Li, Qijun; Pan, Weisan; Yang, Xinggang

doi:10.1208/s12249-018-1237-3

Cited by 50 publications

(19 citation statements)

References 38 publications

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“…The tablets were then fabricated from the prepared paste using a commercial microextrusion 3D printer (Fochif Mechatronics Technology Co., Ltd., Shanghai, China) at room temperature [ 62 ]. Likewise, a commercial pressure-assisted syringes 3D printer (Fochif Mechatronics Technology Co., Ltd., Shanghai, China) was employed to produce gastro-retentive drug delivery systems loaded with ginkgolide at a printing temperature of 25 °C [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.

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Section: Resultsmentioning

confidence: 99%

3D Printing of Thermo-Sensitive Drugs

et al. 2021

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“…The higher the viscosity, the higher the resolution [ 118 , 119 ]. This technique has been widely used for the manufacture of drugs [ 120 , 121 , 122 , 123 ] and, to a lesser extent, to make polymer scaffolds [ 118 , 119 ]. The same research group [ 124 , 125 , 126 ] developed the so-called PAM 2, in which they replaced constant pressure with a mechanical piston as the driving force.…”

Section: Discussionmentioning

confidence: 99%

Main 3D Manufacturing Techniques for Customized Bone Substitutes. A Systematic Review

et al. 2021

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Clinicians should be aware of the main methods and materials to face the challenge of bone shortage by manufacturing customized grafts, in order to repair defects. This study aims to carry out a bibliographic review of the existing methods to manufacture customized bone scaffolds through 3D technology and to identify their current situation based on the published papers. A literature search was carried out using “3D scaffold”, “bone regeneration”, “robocasting” and “3D printing” as descriptors. This search strategy was performed on PubMed (MEDLINE), Scopus and Cochrane Library, but also by hand search in relevant journals and throughout the selected papers. All the papers focusing on techniques for manufacturing customized bone scaffolds were reviewed. The 62 articles identified described 14 techniques (4 subtraction + 10 addition techniques). Scaffold fabrication techniques can be also be classified according to the time at which they are developed, into Conventional techniques and Solid Freeform Fabrication techniques. The conventional techniques are unable to control the architecture of the pore and the pore interconnection. However, current Solid Freeform Fabrication techniques allow individualizing and generating complex geometries of porosity. To conclude, currently SLA (Stereolithography), Robocasting and FDM (Fused deposition modeling) are promising options in customized bone regeneration.

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“…The suggestions made by participants in our study for a food-like HIV prevention method provide avenues for innovation to create an aspirational health, instead of illness, platform for HIV prevention. Already, 3D printing technology science can print food [ 28 ] and is investigating the printing of medication [ 29 ] and nutraceuticals [ 30 ]. Printing HIV prevention medication into food is not a far-fetched prospect.…”

Section: Discussionmentioning

confidence: 99%

Willingness to use HIV prevention methods among vaccine efficacy trial participants in Soweto, South Africa: discretion is important

et al. 2020

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Background Despite multiple available HIV prevention methods, the HIV epidemic continues to affect South Africa the most. We sought to understand willingness to use actual and hypothetical HIV prevention methods among participants enrolled in a preventative HIV vaccine efficacy trial in Soweto, South Africa. Methods We conducted a qualitative study with 38 self-reporting HIV-uninfected and consenting 18–35 year olds participating in the HVTN 702 vaccine efficacy trial in Soweto. Using a semi-structured interview guide, five focus group discussions (FGDs) were held, stratified by age, gender and sexual orientation. The FGDs were composed of: (i) 10 heterosexual women aged 18–24 years; (ii) 9 heterosexual and bisexual women aged 25–35 years; (iii & iv) heterosexual men aged 25–35 years with 7 in both groups; and (v) 5 men aged 18–35 years who have sex with men. FGDs were audio-recorded, transcribed verbatim, translated into English and analysed using thematic analysis. Results We present five main themes: (i) long-lasting methods are preferable; (ii) condoms are well-known but not preferred for use; (iii) administration route of HIV prevention method is a consideration for the user; (iv) ideal HIV prevention methods should blend into the lifestyle of the user; and the perception that (v) visible prevention methods indicate sexual indiscretion. Conclusions The participants’ candour about barriers to condom and daily oral pre-exposure prophylaxis (PrEP) use, and expressed preferences for long-lasting, discreet, lifestyle-friendly methods reveal a gap in the biomedical prevention market aiming to reduce sexually acquired HIV in South Africa. Product developers should consider long-acting injectable formulations, such as vaccines, passive antibodies and chemoprophylaxis, for HIV prevention technologies. Future innovations in HIV prevention products may need to address the desire for the method to blend easily into lifestyles, such as food-medication formulations.

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Structure-Based Gastro-Retentive and Controlled-Release Drug Delivery with Novel 3D Printing

Cited by 50 publications

References 38 publications

3D Printing of Thermo-Sensitive Drugs

3D Printing of Thermo-Sensitive Drugs

Main 3D Manufacturing Techniques for Customized Bone Substitutes. A Systematic Review

Willingness to use HIV prevention methods among vaccine efficacy trial participants in Soweto, South Africa: discretion is important

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