Structure, bioactivity, and synthesis of methylated flavonoids

Wen, Li; Jiang, Yueming; Yang, Jiali; Zhao, Yupeng; Tian, Miaomiao; Yang, Bao

doi:10.1111/nyas.13350

Cited by 139 publications

(79 citation statements)

References 58 publications

(111 reference statements)

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“…Flavonoids are a large group of polyphenolic products widely distributed in vegetables, fruits, and beverages such as wine and tea 102 , 103 . Recent research has revealed that some natural flavonoids are strong inhibitor against both CES1 and CES2 ( Fig.…”

Section: Ces Inhibitorsmentioning

confidence: 99%

Human carboxylesterases: a comprehensive review

Wang

Zou

Jin

et al. 2018

Acta Pharmaceutica Sinica B

393

268

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Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) have been identified and extensively studied over the past decade. These two enzymes play crucial roles in the metabolism of a wide variety of endogenous esters, ester-containing drugs and environmental toxicants. The key roles of CES in both human health and xenobiotic metabolism arouse great interest in the discovery of potent CES modulators to regulate endobiotic metabolism or to improve the efficacy of ester drugs. This review covers the structural and catalytic features of CES, tissue distributions, biological functions, genetic polymorphisms, substrate specificities and inhibitor properties of CES1 and CES2, as well as the significance and recent progress on the discovery of CES modulators. The information presented here will help pharmacologists explore the relevance of CES to human diseases or to assign the contribution of certain CES in xenobiotic metabolism. It will also facilitate medicinal chemistry efforts to design prodrugs activated by a given CES isoform, or to develop potent and selective modulators of CES for potential biomedical applications.

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Section: Ces Inhibitorsmentioning

confidence: 99%

Human carboxylesterases: a comprehensive review

Wang

Zou

Jin

et al. 2018

Acta Pharmaceutica Sinica B

393

268

View full text Add to dashboard Cite

show abstract

“…One factor that could affect TAC is antioxidant bioavailability in vivo because TAC is a parameter that is estimated in vitro [ 55 ]. Antioxidant bioavailability differs depending on the type of antioxidant, such as methylated flavonoids [ 56 ], cooking and processing conditions [ 57 , 58 ], and digestion stages, including the influence of microflora in the colon [ 58 ]. Thus, well designed studies to determine the relationship between TAC and MetS that also consider antioxidant bioavailability are required.…”

Section: Discussionmentioning

confidence: 99%

Total Antioxidant Capacity from Dietary Supplement Decreases the Likelihood of Having Metabolic Syndrome in Korean Adults

et al. 2017

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This study was conducted to estimate antioxidant vitamin intake and total antioxidant capacity (TAC) from diet and dietary supplements and to examine their association with metabolic syndrome (MetS) in Korean adults. Out of 6308 adults 19~64 years old from the 2010~2011 Korea National Health and Nutrition Examination Survey, 1847 adults were classified as dietary supplement users and the other 4461 adults were classified as non-users. Antioxidant intake and TAC from diet and dietary supplements were estimated using dietary intake data and linked with the antioxidant and TAC database for common Korean foods. The prevalence of MetS was lower in dietary supplement users (odds ratio (OR) = 0.82; 95% confidence interval (CI), 0.68–0.98) than that in non-users. Among dietary supplement users, a lower prevalence of MetS was observed in the highest tertile for vitamin A (OR = 0.72; 95% CI, 0.53–0.99) and vitamin E (OR = 0.74; 95% CI, 0.55–0.99) intake than that in the lowest tertile among non-users. Subjects in the highest tertile of TAC among dietary supplement users showed a lower prevalence of MetS (OR = 0.72; 95% CI, 0.52–0.99) than non-users. The results imply that intake of vitamin A, vitamin E, and TAC from dietary supplements might have a protective effect on MetS among Korean adults.

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“…Flavonoids are a kind of natural polyphenols, mainly including flavonoids, flavanols, flavonoids, anthocyanins, and isoflavones [225]. Studies had shown that flavonoids had definite efficacy in the treatment of agerelated neurodegenerative diseases [226], cardiovascular diseases [227,228], atherosclerosis [229], etc.…”

Section: Flavonoidsmentioning

confidence: 99%

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

Liu

Wei-liang

Gao

et al. 2019

Oxidative Medicine and Cellular Longevity

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Aging is a progressive disease affecting around 900 million people worldwide, and in recent years, the mechanism of aging and aging-related diseases has been well studied. Treatments for aging-related diseases have also made progress. For the long-term treatment of aging-related diseases, herbal medicine is particularly suitable for drug discovery. In this review, we discuss cellular and molecular mechanisms of aging and aging-related diseases, including oxidative stress, inflammatory response, autophagy and exosome interactions, mitochondrial injury, and telomerase damage, and summarize commonly used herbals and compounds concerned with the development of aging-related diseases, including Ginkgo biloba, ginseng, Panax notoginseng, Radix astragali, Lycium barbarum, Rhodiola rosea, Angelica sinensis, Ligusticum chuanxiong, resveratrol, curcumin, and flavonoids. We also summarize key randomized controlled trials of herbal medicine for aging-related diseases during the past ten years. Adverse reactions of herbs were also described. It is expected to provide new insights for slowing aging and treating aging-related diseases with herbal medicine.

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Structure, bioactivity, and synthesis of methylated flavonoids

Cited by 139 publications

References 58 publications

Human carboxylesterases: a comprehensive review

Human carboxylesterases: a comprehensive review

Total Antioxidant Capacity from Dietary Supplement Decreases the Likelihood of Having Metabolic Syndrome in Korean Adults

New Insights for Cellular and Molecular Mechanisms of Aging and Aging-Related Diseases: Herbal Medicine as Potential Therapeutic Approach

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