Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from <i>Dendrobium officinale</i> on acute ethanol-induced gastritis

Zhu, Hua; Xu, Lei; Chen, Peng; Li, Zhenhao; Yu, Wujin; Sun, Peilong; Wu, Jianyong; Cai, Ming

doi:10.1039/d3fo05540j

Food Funct.

2024

DOI: 10.1039/d3fo05540j

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Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from Dendrobium officinale on acute ethanol-induced gastritis

Hua Zhu,

Lei Xu,

Peng Chen

et al.

Abstract: Gastritis is a common disease characterized by gastric ulcer and more severe bleeding. Daily intake of large amounts of alcohol can cause acute gastritis, which brings inconvenience to people's lives....

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Cited by 2 publications

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Structural characteristics of a purified Evodiae fructus polysaccharide and its gastroprotection and relevant mechanism against alcohol-induced gastric lesions in rats

Wang,

Hao,

et al. 2024

International Journal of Biological Macromolecules

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Structural characteristics of a purified Evodiae fructus polysaccharide and its gastroprotection and relevant mechanism against alcohol-induced gastric lesions in rats

Wang,

Hao,

et al. 2024

International Journal of Biological Macromolecules

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Identification of Protein Hydrolysates from Sesame Meal and In Vivo Study of Their Gastric Mucosal Protective Effects

Yuan,

Wang,

Ling

et al. 2024

Foods

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This study aimed to investigate the protective effects and defense mechanisms of a sesame meal protein hydrolysate against ethanol-induced acute gastric mucosal injury in mice. The target peptides in the hydrolysate were identified by LC-MS/MS, the activity was predicted by PeptideRanker, and the KM mice were orally administered distilled water, a sesame peptide, and omeprazole for 24 consecutive days. Acute gastric mucosal injury was then induced in mice with 70% ethanol, except for the CK group. The sesame peptide significantly inhibited the over-accumulation of ALT, AST, MDA, TNF-α, IL-1β, and MPO, while promoting the reduction in GSH, T-AOC, GSSG, and EGF expression. In addition, a Western blotting analysis showed that sesame peptide significantly up-regulated the expression of HO-1 and NQO1 proteins in the Nrf2/Keap1 signaling pathway, and down-regulated Keap1 protein. The defense effect of a sesame peptide on gastric mucosa may be achieved by alleviating the overproduction of lipid peroxides and improving the antioxidant activity.

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Structure characteristics, protective effect and mechanisms of ethanol-fractional polysaccharides from Dendrobium officinale on acute ethanol-induced gastritis

Abstract: Gastritis is a common disease characterized by gastric ulcer and more severe bleeding. Daily intake of large amounts of alcohol can cause acute gastritis, which brings inconvenience to people's lives....

Cited by 2 publications

References 54 publications

Structural characteristics of a purified Evodiae fructus polysaccharide and its gastroprotection and relevant mechanism against alcohol-induced gastric lesions in rats

Structural characteristics of a purified Evodiae fructus polysaccharide and its gastroprotection and relevant mechanism against alcohol-induced gastric lesions in rats

Identification of Protein Hydrolysates from Sesame Meal and In Vivo Study of Their Gastric Mucosal Protective Effects

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