Structure-color correlations of penta- and heptamethines

Novel pyrimidine and its triazole fused derivatives: Synthesis and investigation of antioxidant and anti-inflammatory activity

“…Pyrimidine, being an integral part of DNA and RNA, imparts to diverse pharmacological properties as effective bactericide and fungicide (Williams and Cline, 1936;Reidlinger and Dworczak, 1994;Hardtman and Otto, 1972). Certain pyrimidine derivatives were also known to exhibit antimalarial (Brown and Evans, 1985), antifilarial ( Brown and Rees, 1984), antioxidant (Vanessa et al, 2010;Prasenjit et al, 2010) and anti-HIV activities (Okabe et al, 1991).…”

A convenient synthesis of some new fused pyridine and pyrimidine derivatives of antimicrobial profiles

“…1,6-Diamino-3,5-dicyano-4-(5-methylfuran-2-yl)-2-pyridone (3), [15] was prepared in a good yield by reacting 2-((5-methylfuran-2-yl)methylene)malononitrile (1) with cyanoacetohydrazide (2) On the other hand, the thioxopyrimidine heterocyclic core were constructed according to Biginelli reaction by a cyclo-condensation of equivalent molar quantities of 5-methylfurfural, thiourea, and ethyl cyanoacetate in sodium ethoxide solution. After neutralization with acid, the desired 5-cyano-4-oxo-6-(5-methylfuran-2-yl)-2-thioxo-1,2,3,4-tetrahydro-pyrimidine derivative (8) Antimicrobial assay…”

“…In addition to the previously mentioned properties, thiazolo [3,2-a]pyridines, also containing two fused heterocyclic moieties in one molecule, are found in a broad range of biologically active compounds and have many important bioactivities such as inhibitors of beta-amyloid production [8], CDK2-cyclin-A [9], and a-glucosidase [10], potential uterus stimulants [11,12], and antibacterial and antifungal activities [13], and are found to exhibit a broad spectrum of potent anticancer activity and are useful for chemotherapy of various cancers, such as leukemia, lung cancer, and melanoma [14]. On the other hand, certain pyrimidine derivatives are also known to exhibit diverse pharmacological properties such as effective bactericides and fungicides [15], as antimalarial [16], antioxidant [17,18], and antihypertensive agents, as adrenergic and neuropeptide antagonists [19] and having anti-HIV activities [20,21]. Along with the varied biological activities of pyrimidine, other heterocycles fused with pyrimidines play an essential role in several biological processes and have a considerable chemical and pharmacological importance [22,23].…”

Design, Synthesis, and Evaluation of a Dye Library: Glass-Forming and Solid-State Luminescent Merocyanines for Functional Materials

“…Prompted by the recent description of a formylation ± condensation sequence for the synthesis of merocyanines in which orthoformates [8] were used, we examined a series of formic acid derivatives in diverse solvents for their suitability for the synthesis of the dyes 3 and 4 from the reactants 7 and 8 or 9, respectively (Scheme 1).…”

“…[2] High concentrations of colorant are necessary in photorefractive materials, ribbons for thermal dye transfer printing, and toners for color copiers, which leads to problems due to 1994, 1167. [8] The bicyclic skeleton of the dimer is isostructural with a known analogue [15] prepared from the monomer of 3,4-dimethylphosphole. The tert-butyl groups in dimer 3 induce very little distortion of the bicyclic skeleton; the PÀP and CÀC distances lie within the statistical errors of the known compound.…”