Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro

Šťastný, Přemysl; Sedláček, Radek; Suchý, Tomáš; Lukášová, Věra; Rampichová, Michala; Trunec, Martin

doi:10.1016/j.msec.2019.03.027

Cited by 50 publications

(35 citation statements)

References 40 publications

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“…As the soaking time increased, the number and range of micropores gradually increased, eventually leading to the shedding of entire particles or the parts connected by micropores. This study showed a similar pattern of results compared to previous studies [14,41].…”

Section: Apatite Deposition and Degradation In Sbfsupporting

confidence: 91%

“…On the one hand, TCP is a bioactive calcium phosphate ceramic with a higher degradation rate than HA. On the other hand, biphasic calcium phosphate (BCP) consisting of TCP and undecomposed HA has been proven to have better mechanical properties and osteogenetic ability than the single phase [14,30]. In addition, calcium oxide, another decomposition product of HA, can dissolve into the interior of the zirconia crystal, changing the original crystal structure [31].…”

Section: Surface Morphology and Composition Analysismentioning

confidence: 99%

“…Even so, the degradation rate of this kind of ceramic in the body is often too fast, and does not match the osteogenesis speed. In addition, its mechanical properties are poor, and will be further weakened during the degradation process and cannot meet the requirements over a long period of time [14]. All these properties limit the use of degradable ceramics as load-bearing bone repair materials; they are usually used as hard tissue fillers.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing

Cao

Shi

Jiao

et al. 2020

Ceramics International

107

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Section: Apatite Deposition and Degradation In Sbfsupporting

confidence: 91%

Section: Surface Morphology and Composition Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing

Cao

Shi

Jiao

et al. 2020

Ceramics International

107

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“…Taking account the values of compressive strength in natural bone, the selected scaffold (ATE-G3-4, labelled as ATE-G3 in general) ensures to gather two necessary properties for an ideal bone substitute: porosity and mechanical property being this value around 87 ± 22 MPa. This value is really higher compared with the results obtained for Repros (BCP) scaffold and found values to those reported in the literature for bioglass and calcium phosphate scaffolds 44 - 46 . The improvement of the mechanical properties in case of ATE-G3 scaffolds could be ascribed to the nepheline phase (Fig.…”

Section: Discussioncontrasting

confidence: 48%

Novel antimicrobial phosphate-free glass–ceramic scaffolds for bone tissue regeneration

Suárez

Fernández-García

Fernández

et al. 2020

Sci Rep

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In this study a phosphate-free glass-ceramic porous scaffold was synthesized by a three-step methodology involving slurry preparation, induction of porosity by surfactant-assisted foaming following by freeze-drying and sintering. This inorganic scaffold was characterized by X-ray diffraction, scanning electron microscope (SEM), degradation and bioactivity. Thermal treatment at 750 °C showed two new crystalline phases, combeite and nepheline, into the glassy matrix responsible for its properties. The cell response of the scaffold was also evaluated for using as a bone graft substitute. A commercial Biphasic Calcium Phosphate, BCP, scaffold was assessed in parallel as reference material. Microstructures obtained by SEM showed the presence of macro, meso and microporosity. The glass-ceramic scaffold possesses an interconnected porosity around 31% with a crack-pore system that promote the protein adsorption and cell attachment. Glass-ceramic scaffold with high concentration of calcium ions shows an antimicrobial behavior against Escherichia coli after 24 h of contact. nepheline phase present in the glass-ceramic structure is responsible for its high mechanical properties being around 87 MPa. Glass-ceramic scaffold promotes greater protein adsorption and therefore the attachment, spreading and osteodifferentiation of Adipose Derived Stem Cells than BCP scaffold. A higher calcification was induced by glass-ceramic scaffold compared to reference BCP material.

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“…With the loading of near-infrared pH fluorescent probes, in vivo microenvironment investigation could be realized. 49 This technique was based on the analysis of the fluorescence intensity by fluorescence microscopy, which would induce variations. The procedure of constructing the pH color map of the ratiometric images could also be optimized for wider compatibility and needs further investigation.…”

Section: Resultsmentioning

confidence: 99%

Ratiometric Fluorescent Microgels for Sensing Extracellular Microenvironment pH during Biomaterial Degradation

Liu

et al. 2020

ACS Omega

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Bone regeneration has attracted extensive attention in the field of regenerative medicine. The influence of biomaterial on the extracellular environment is important for regulating the biological functions of cells for tissue regeneration. Among the various influencing factors, we had previously demonstrated that the extracellular pH value in the local microenvironment during biomaterial degradation affected the balance of bone formation and resorption. However, there is a lack of techniques for conveniently detecting the pH of the extracellular environment. In light of the development of fluorescent pH-sensing probes, herein, we fabricated a novel ratiometric fluorescent microgel (F-MG) for real-time and spatiotemporal monitoring of microenvironment pH. F-MGs were prepared from polyurethane with a size of around 75 μm by loading with pH-sensitive bovine serum albumin nanoparticles (BNPs) and pH-insensitive Nile red as a reference. The pH probes exhibited reversible fluorescence response to pH change and worked in a linear range of 6–10. F-MGs were biocompatible and could be used for long-term pH detection. It could be used to map interfacial pH on biomaterials during their degradation through pseudocolored images formed by the fluorescence intensity ratio between the green fluorescence of BNPs and the red fluorescence of Nile red. This study provided a useful tool for studying the influence of biomaterial microenvironment on biological functions of surrounding cells.

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Structure degradation and strength changes of sintered calcium phosphate bone scaffolds with different phase structures during simulated biodegradation in vitro

Cited by 50 publications

References 40 publications

Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing

Fabrication and properties of zirconia/hydroxyapatite composite scaffold based on digital light processing

Novel antimicrobial phosphate-free glass–ceramic scaffolds for bone tissue regeneration

Ratiometric Fluorescent Microgels for Sensing Extracellular Microenvironment pH during Biomaterial Degradation

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