Structure determination of nitrato-κO-bis[2-(2-pyridyl-κN)amino-5,6-dihydro-4H-1,3-thiazine-κN]copper(II) nitrateviamolecular modelling coupled with X-ray powder diffractometry

Garcı́a-Cuesta, M.C.; Lozano, A. M.; Meléndez, Juan J.; Luna‐Giles, F.; Ortiz, Ángel L.; González-Méndez, L.M.; Cumbrera, F.L.

doi:10.1107/s0021889804024653

Cited by 13 publications

(2 citation statements)

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“…In this sense, the ligand 2-(2-pyridyl)iminotetrahydro-1,3-thiazine (PyTz), which contains a 1,3-thiazine ring and a pyridine ring in its structure and has been previously used in our group for the synthesis of several transition metal complexes [ 23 , 24 , 25 ], could be a promising ligand in the synthesis of Pt(II) and Pd(II) complexes with antitumor activity.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

et al. 2021

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Chemical, pharmacological, and clinical research on anticancer coordination complexes has led to noteworthy anticancer drugs such as cisplatin, carboplatin and oxaliplatin. Although these compounds are effective chemotherapeutic agents in the treatment of different tumors, they are associated with high toxicity and numerous side effects. Several studies have shown that the range of platinum complexes with antitumor activity is not limited to structural analogs of cisplatin. Therefore, the development of convenient anticancer drugs that can be effectively used for the treatment of human tumors has become the main goal of most research groups in this field. In this sense, active platinum complexes without NH groups, transplatinum complexes, multinuclear complexes, cationic complexes, and several classes of palladium(II) complexes have emerged. Herein, the synthesis and characterization of two Pt(II) or Pd(II) complexes with PyTz (2-(2-pyridyl)iminotetrahydro-1,3-thiazine), a thiazine derivative ligand, with the formula [MCl2(PyTz)]·C2H6O (M = Pt(II) or Pd(II)) were reported. The potential anticancer ability of both complexes was evaluated in epithelial cervix carcinoma HeLa, human ovary adenocarcinoma SK-OV-3, human histiocytic lymphoma U-937, and human promyelocytic leukemia HL-60 cell lines. Interestingly, the Pt(II) complex showed great cytotoxic potential against all tumor cell lines tested, whereas the Pd(II) complex displayed slight antitumor actions.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

et al. 2021

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“…Reports on structure determinations or spectroscopic characterizations of triphenyltin(IV) derivatives with monoand polybasic oxyanions (XO m n -; X = Cr, Se, S, As; m = 3, 4; n = 1, 2, 3) show that the oxyanions behave mainly as polydentate ligands involving a one-dimensional polymeric, bi-or tridimensional network structure (Molloy et al, 1989;Diop et al, 2002;Diass é -Sarr et al, 2004;Fall et al, 2010;Boye et al, 2012). Some nitrato derivatives (Jurkschat et al, 2003a;Garc í a-Cuesta et al, 2004;Seward et al, 2007;Anjaneyulu et al, 2010;Hakimi et al, 2012) (Sall et al, 1995;Diallo et al, 2009;Gueye et al, 2011;Diop et al, 2013). In this paper, we report on the reactions between tetraethylammonium nitrate (Et 4 NNO 3 ) or dicyclohexylammonium nitrate (Cy 2 NH 2 NO 3 ) and mixing triphenyltin(IV) chloride (SnPh 3 Cl) or SnR 2 Cl 2 (R = Ph, Bu), which have yielded a trinuclear organostannate complex and related derivatives.…”

Section: Introductionmentioning

confidence: 99%

Et4N[NO3(SnClPh3)2(SnPh3NO3)]: a trinuclear organostannate complex and related derivatives

Diop¹,

Diop²,

Michaud³

et al. 2013

Main Group Metal Chemistry

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Four new di-and triorganonitrato stannate complexes and related derivatives have been synthesized and characterized by infrared and M ö ssbauer spectroscopy. The structure of Et 4 N[NO 3 (SnClPh 3 ) 2 (SnPh 3 NO 3 )] ( 1 ) has been determined by single-crystal X-ray diffraction analysis. In the trinuclear organostannate complex, each Sn IV atom is five-coordinated and adopts a trigonal-bipyramidal trans -OXSnC 3 (X = O or Cl) geometry. The overall coordination environment of the Sn IV atoms is trans-octahedral for 2 and 3 or cis-trigonal-bipyramidal for 4 . In the related derivatives, the NO 3 -anions behave as monodentate ligands.

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Magnetic, Spectroscopic and Thermal Study of [Cu(NO₃)(PyTz)₂](NO₃). A Copper(II) Complex Containing Thiazine Derivative Ligand

Barros-García

Bernalte‐García

Lozano-Vila

et al. 2005

Zeitschrift anorg allge chemie

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The copper(II) complex [Cu(NO 3 )(PyTz) 2 ](NO 3 ) has been previously characterized means X-ray powder diffraction and now studied by IR spectroscopy, UV-Vis-NIR diffuse reflectance, magnetic susceptibility measurement, electronic spin resonance (ESR) and thermal analysis. The results are correlated with a distorted square pyramidal coordination around copper(II) ion rather than the cis-distorted octahedral stereochemistry of a CuN 4 OOЈ chromophore in good concordance with their structure. Likewise, in order to indicate towards what square pyramidal isomer the 947 complex is distorted, the method proposed by Carugo and Bisi has been applied to the structural data of [Cu(NO 3 )(PyTz) 2 ](NO 3 ). It is deduced that there is a large distortion from the trigonal bipyramid geometry, close to a square pyramid geometry, being produced almost exclusively through the B route of the Berry mechanism. 1 H-NMR (deuteriochloroform): δ 10.93 (s, 1H), 8.15 (d, J ϭ 4.82 Hz, 1H), 7.58 (t, J ϭ 7.71 Hz, 1H), 6.84 (m, 2H), 3.45 (t, J ϭ 5.12 Hz, 2H), 3.04 (t, J ϭ 5.92 Hz, 2H), 1.96 (m, 2H); 13 C-NMR (deuteriochloroform): δ 161.0, 146.1, 137.7, 119.1, 116.5, 41.8, 26.9, 22.0. UV-Vis (EtOH): λ max , nm; (ε, L mol Ϫ1 cm Ϫ1 ) 307 (17372), 267 (19249). Preparation of [Cu(NO 3 )(PyTz) 2 ](NO 3 )The preparation of the complex has been carried out as it is described by us [16]. The crystals were separated by filtration, washed with cold ether and air-dried. Found: C,

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Structure determination of nitrato-κO-bis[2-(2-pyridyl-κN)amino-5,6-dihydro-4H-1,3-thiazine-κN]copper(II) nitrateviamolecular modelling coupled with X-ray powder diffractometry

Cited by 13 publications

References 43 publications

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

Et4N[NO3(SnClPh3)2(SnPh3NO3)]: a trinuclear organostannate complex and related derivatives

Magnetic, Spectroscopic and Thermal Study of [Cu(NO₃)(PyTz)₂](NO₃). A Copper(II) Complex Containing Thiazine Derivative Ligand

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Structure determination of nitrato-κO-bis[2-(2-pyridyl-κN)amino-5,6-dihydro-4H-1,3-thiazine-κN]copper(II) nitrateviamolecular modelling coupled with X-ray powder diffractometry

Cited by 13 publications

References 43 publications

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

Synthesis, Characterization and Antiproliferative Evaluation of Pt(II) and Pd(II) Complexes with a Thiazine-Pyridine Derivative Ligand

Et4N[NO3(SnClPh3)2(SnPh3NO3)]: a trinuclear organostannate complex and related derivatives

Magnetic, Spectroscopic and Thermal Study of [Cu(NO3)(PyTz)2](NO3). A Copper(II) Complex Containing Thiazine Derivative Ligand

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Magnetic, Spectroscopic and Thermal Study of [Cu(NO₃)(PyTz)₂](NO₃). A Copper(II) Complex Containing Thiazine Derivative Ligand