Structure Elucidation of a New Lignan Glycoside from Artemisia ordosica

Wang, Qinghu; Jun-hua, Gong; Hao, Junsheng; Xu, Yang

doi:10.1007/s10600-019-02880-8

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…The chemical constituents of A. ordosica are abundant and diverse, including flavonoids [ 16 ], terpenes [ 17 , 18 ], polysaccharides, sterols [ 19 ], coumarins [ 20 ], phenylpropanoids [ 17 ], organic acids, amino acids, and microelements [ 15 ]. In recent years, some compounds have been isolated, including a new lignan glycoside (artemordolignan glycoside A) [ 21 ], a new coumarin having a new skeleton (arteordocoumarin A) [ 22 ], four new compounds (arteordoyn A, arteordoyn B, arteordosin A, and arteordosin B) [ 23 , 24 ], and five polyacetylenes (capillene, capillinol, capillin, trans-dehydromatricaria ester, and cis-dehydromatricariaria ester) [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation of Broad-Spectrum Fungicidal Active Compound from Artemisia ordosica

Tang

Yang

et al. 2021

Metabolites

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To avoid the widespread resistance of commercial fungicides, new broad-spectrum botanical fungicides need to be developed. In previous bioactive screening assays, extracts of Artemisia ordosica Krasch. (A. ordosica) had highly antifungal activities, but the responsible phytochemicals were unidentified. In this study, active compounds of A. ordosica extracts were identified using a bioassay-guided method, and antifungal assays were performed in vitro and in vivo. The bioactive compounds were dissolved in petroleum ether, and the best antifungal fraction contained four compounds: trans-dehydromatricaria ester (TDDE), 7, 4-demetylnringenin, capillarin, and stearic acid. Among them, TDDE exhibited the highest antifungal activity against six pathogenic fungi and five bacteria. It exhibited significant fungicidal activity against Thanatephorus cucumeris and Botrytis cinerea with EC50 values of 0.464 μg/mL and 1.4 μg/mL, respectively. The living tissue bioassay results showed that the relative protection effects (RPE) of TDDE on tomato leaves, tomato fruit, and strawberry leaves infected with B. cinerea reached 76.78%, 86.2%, and 80.89%, respectively. In pot experiments, the RPE on tomato and strawberry plants infected with B. cinerea reached 84.11% and 96.37%, respectively. Morphological and physiological examination showed that TDDE had significant inhibitory effects on mycelial growth, including increased top offshoot, contorted hyphal tips, and extravasated cytochylema. Meanwhile, bactericidal activities of TDDE were significantly higher than kanamycin and streptomycin in five bacteria, and the plant tissue experiments further demonstrated that it had an 88.31% RPE on walnut leaves infected with Xanthomonas campestris pv. jugiandis, 72.18% RPE on potato infected with Erwinia carotovora subsp. carotovora, and 82.50% RPE on kiwifruit branches infected with Pseudomonas syringae pv. actinidiae. The active compounds isolated from A. ordosica in this study show great potential value for developing broad-spectrum fungicides, and also provide an important way to identify and isolate new bioactive products from medicinal plants.

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Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation of Broad-Spectrum Fungicidal Active Compound from Artemisia ordosica

Tang

Yang

et al. 2021

Metabolites

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“…The Artemisia secondary metabolites belong to the several organic compounds families [ 44 , 47 , 48 , 49 ] such as terpenoids [ 14 , 44 ], mostly monoterpenes in essential oils [ 31 , 44 ] and sesquiterpene lactones [ 40 , 41 , 50 ], flavonoids [ 14 , 46 , 51 , 52 ], lignans [ 52 , 53 , 54 , 55 ], alkaloids [ 56 ], steroids [ 14 , 57 ], phenolic acids [ 37 , 47 , 58 ] and coumarins [ 14 , 53 , 59 ], all of them well known for their large range of biological activities.…”

Section: Introductionmentioning

confidence: 99%

Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents

Трендафилова

Moujir

Sousa

et al. 2020

Foods

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The genus Artemisia, often known collectively as “wormwood”, has aroused great interest in the scientific community, pharmaceutical and food industries, generating many studies on the most varied aspects of these plants. In this review, the most recent evidence on health effects of edible Artemisia species and some of its constituents are presented and discussed, based on studies published until 2020, available in the Scopus, Web of Sciences and PubMed databases, related to food applications, nutritional and sesquiterpene lactones composition, and their therapeutic effects supported by in vivo and clinical studies. The analysis of more than 300 selected articles highlights the beneficial effect on health and the high clinical relevance of several Artemisia species besides some sesquiterpene lactones constituents and their derivatives. From an integrated perspective, as it includes therapeutic and nutritional properties, without ignoring some adverse effects described in the literature, this review shows the great potential of Artemisia plants and some of their constituents as dietary supplements, functional foods and as the source of new, more efficient, and safe medicines. Despite all the benefits demonstrated, some gaps need to be filled, mainly related to the use of raw Artemisia extracts, such as its standardization and clinical trials on adverse effects and its health care efficacy.

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Artemordosins A−L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica

Wang,

Li,

et al. 2025

Phytochemistry

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Structure Elucidation of a New Lignan Glycoside from Artemisia ordosica

Cited by 3 publications

References 4 publications

Bioassay-Guided Isolation of Broad-Spectrum Fungicidal Active Compound from Artemisia ordosica

Bioassay-Guided Isolation of Broad-Spectrum Fungicidal Active Compound from Artemisia ordosica

Research Advances on Health Effects of Edible Artemisia Species and Some Sesquiterpene Lactones Constituents

Artemordosins A−L, cadinane-monoterpene heterodimers and sesquiterpenoids with antihepatoma activity from Artemisia ordosica

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