Structure elucidation of an unusual new sesquiterpene lactone glucoside ester from Crepis pannonica

Three new trixane glycosides obtained from the leaves of Jungia sellowii Less. using centrifugal partition chromatography

“…The last ring was established from the HMBC correlations observed between the protons of Me-12 and carbons C-2 (δ 43.0), C-10 (δ 65.2), C-11 (δ 47.7), and C-13 (δ 76.4). The sugar moiety was identified as glucopyranosyl by comparing its chemical shift with those formerly reported [ 35 ]. It was further attached to the aglycone at C-13 since H-13 (δ 3.39, 3.82) correlated with the anomeric carbon (104.7).…”

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

“…(6S,7S,10R)-3-Oxo-di-nor-eudesm-4-en-6a-hydroxy-11-oic acid (1). Amorphous yellow solid; ½a 20 D +97.6 (c 0.02, MeOH); UV (MeOH) l max 248 nm; 1 H NMR and 13 C NMR see ESI…”

“…11 Based on searching the reported literature of the genus Crepis, its aerial parts were reported to be rich in both avonoid aglycones and glycosides 12 in addition to eudesmanes and guaianolides sesquiterpenes present as both aglycone and glycosidic forms. 13 Regarding assessed bioactivities, the extracts of genus Crepis have been reported to possess antimicrobial, antiviral and antiproliferative activities together with antioxidant, analgesic, antiulcer and anti-inammatory. 12,13 In this study, we report phytochemical exploration of polyphenolic-rich extract of C. sancta aerial parts affording ten different compounds belonging to eudesmane sesquiterpenes and methoxylated avonoids.…”

“…13 Regarding assessed bioactivities, the extracts of genus Crepis have been reported to possess antimicrobial, antiviral and antiproliferative activities together with antioxidant, analgesic, antiulcer and anti-inammatory. 12,13 In this study, we report phytochemical exploration of polyphenolic-rich extract of C. sancta aerial parts affording ten different compounds belonging to eudesmane sesquiterpenes and methoxylated avonoids. Structure elucidation of isolated compounds was unambiguously conrmed through HRESIMS, exhaustive 1D, 2D NMR spectroscopy and X-ray crystallography.…”

Estudo metabolômico de espécies invasoras de Asteraceae visando a descoberta de substâncias ativas contra a praga agrícola >i<Chlosyne lacinia>/i< Geyer (Lepidoptera: Nymphalidae)

“…A tribo Senecioneae, a que pertence a espécie bioativa E. fosbergii, apresenta em seu arsenal metabólico alcaloides pirrolizidínicos (APs) e alcaloides do tipo N-óxido (MROCZEK et al, 2004) 2008;YAE et al, 2009;KIM et al 2010;LI et al, 2015;MICHALSKA et al, 2016).…”