Structure, Function, and Regulation of Insulin‐like Growth Factors in Fish

Bail, Pierre‐Yves Le; Gentil, Valérie; Noël, Olivier; Gómez, J Montero; Carré, Fabienne; Goff, Pascale Le; Weil, Claudine

doi:10.1111/j.1749-6632.1998.tb10750.x

Cited by 26 publications

(12 citation statements)

References 35 publications

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“…Under anabolic conditions, GH released from the pituitary enters the circulation and binds to hepatic GH receptors, stimulating the synthesis and release of IGF-I into the bloodstream. Insulin-like growth factor-I, a 7.5-kDa single-chain polypeptide, is responsible for cell differentiation and proliferation, the stimulation of processes related to skeletal elongation, and ultimately for body growth (see Duan 1997 andLe Bail et al 1998 for reviews). Plasma IGF-I, in turn, acts in a negative feedback fashion to inhibit GH secretion from the pituitary (Fruchtman et al 2000).…”

mentioning

confidence: 99%

Endocrine Biomarkers of Growth and Applications to Aquaculture: A Minireview of Growth Hormone, Insulin‐Like Growth Factor (IGF)‐I, and IGF‐Binding Proteins as Potential Growth Indicators in Fish

Picha¹,

et al. 2008

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Growth in fish and other vertebrates is under endocrine control, particularly through the growth hormone (GH)-insulin-like growth factor (IGF) axis. For this reason, it has been of interest to aquaculture researchers and the industry to establish endocrine biomarkers that can both reflect and predict growth rates in fish subject to various biotic and abiotic manipulations. Ultimately, by understanding the hormones that control growth and utilizing them as biomarkers, we hope to achieve optimal growth conditions in the aquaculture environment with less need for lengthy and costly grow-out trials. While the most appropriate endocrine biomarkers for growth can be both species and situation specific, IGF-I may be the most promising candidate for measuring instantaneous growth in fish. This is based on the direct contributions of IGF-I in regulating cell proliferation and ultimately somatic growth, along with its previously established correlations with the specific growth rate in fish under various conditions that alter growth. However, other endocrine indices, such as GH and IGF-binding proteins (IGFBPs), are also important contributors and may in some instances prove a strong corollary to growth rate. This review discusses the potential utility of GH, IGF-I, and IGFBPs as growth biomarkers for those manipulations most relevant to the aquaculture industry, namely, feeding regimen, diet composition, temperature, photoperiod, and stress.

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confidence: 99%

Endocrine Biomarkers of Growth and Applications to Aquaculture: A Minireview of Growth Hormone, Insulin‐Like Growth Factor (IGF)‐I, and IGF‐Binding Proteins as Potential Growth Indicators in Fish

Picha¹,

et al. 2008

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“…The IGF/IGFBP system is known to be involved in global body growth of fish (Le Bail et al 1998;Reinecke et al 2005), while its role in adipose tissue growth has been much less studied. We focused on non-edible depots located either in the visceral cavity or subcutaneously and which taken together account for about 20% of body mass, lowering carcass and fillet yields with respect to aquaculture practices.…”

Section: Discussionmentioning

confidence: 99%

The IGF/IGFBP system in rainbow trout (Oncorhynchus mykiss) adipose tissue: expression related to regional localization and cell type

Weil¹,

Lebret²,

Gabillard³

2011

Fish Physiol Biochem

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While in mammals, the IGF/IGFBP system is known to be involved in adipose tissue growth, the presence of such a system in fish is as yet undetermined. The present work aimed at investigating the influence of regional localization of adipose tissues and cell types on the expression of this system. Using quantitative real-time PCR (qPCR), the presence of IGFs, IGFBPs, IGFBP-rPs, and IGFR I (insulin-like growth factors, IGF-binding proteins, IGFBP-related proteins, type I IGF receptor) was studied in crude subcutaneous and visceral fat depots as well as in isolated stromal vascular (SV) cells and mature adipocytes from the latter depot in the prepubescent female rainbow trout. In adipose tissues, no differences were observed in the transcript expressions of IGFs and IGFBPs (1-6) and rP1 relative to their regional localization. On the other hand, the two paralogues of IGFR I were more strongly expressed in visceral than in subcutaneous depots which could be related to a differential receptivity to IGF between fat depots. The amount of IGF-I and IGFR Ia transcripts is larger in mature adipocytes than in SV cells, while a similar level of expression was observed for IGF-II and IGFR Ib. IGFBP-1, -2a, -4, -5, -6, and -rP1 were more strongly expressed in the SV cells than in adipocytes, while IGFBP-2b displayed comparable expression. These results indicate that the IGF/IGFBP system is expressed in rainbow trout fat depots, whatever their regional origin, and that cell types, i.e., SV cells or mature adipocytes, influence its expression.

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“…We expected IGF-I to be a better and more sensitive predictor of recent growth rate in our model based on information in the literature from aquaculture studies and from studies on the role of IGF-I in the direct control of somatic growth (Le Bail et al 1998;Beckman et al 2004;Picha et al 2008a;Beckman 2011). We originally intended to measure levels of IGF-I circulating in plasma, but many of our blood samples were lost in a freezer malfunction.…”

Section: Discussionmentioning

confidence: 99%

“…This approach has been successfully applied in a variety of field applications with larval and small juvenile fish to relate recent growth to habitat conditions over the previous 1-3 d to 2 weeks (Malloy and Targett 1994;Rooker and Holt 1996;Stierhoff et al 2009aStierhoff et al , 2009b. The second bioindicator, IGF-I, is a hormone that is responsible for cell differentiation and proliferation; the stimulation of processes related to skeletal elongation; and, ultimately, somatic growth (see Duan 1997;Le Bail et al 1998 for reviews). Laboratory trials suggest that levels of IGF-I may provide an accurate reflection of variable growth rates in a number of fish species (reviewed by Picha et al 2008a;Beckman 2011).…”

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confidence: 99%

Development and Field Application of a Model Predicting Effects of Episodic Hypoxia on Short‐Term Growth of Spot

Campbell

Rice

2017

Mar Coast Fish

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In North Carolina and elsewhere, there is concern that excessive nutrient loading and resulting hypoxic conditions in coastal ecosystems are adversely affecting the native fauna, but quantifying the effects on fish can be difficult. Hypoxia may reduce fish growth via direct exposure or indirectly (e.g., cost of low‐oxygen avoidance, reduced food availability, and density‐dependent effects in oxygenated refuges). Given the fine spatial and temporal scale of oxygen dynamics in estuarine habitats, evaluating the impacts of hypoxia on fish growth requires short‐term growth indicators that integrate the effects of rapidly changing environmental conditions. To address this need, we experimentally determined the sensitivity and response time of a suite of bioindicators of recent growth (RNA:DNA ratio and RNA concentration in muscle tissue; insulin‐like growth factor‐I messenger RNA expression in the liver; hepatosomatic index; and Fulton's condition factor K) to changes in the specific growth rate of juvenile Spot Leiostomus xanthurus. A model based on multiple bioindicators was better at estimating growth rate than models based on single indicators. We used this model to estimate recent growth rates of juvenile Spot collected from the Neuse River estuary and related them to recent dissolved oxygen (DO) conditions. Estimated growth rates of Spot collected after a week of good DO conditions were almost twice those of Spot collected after a week of poor DO conditions. Using these results and DO data from the Neuse River estuary in 2007–2010, we estimated that hypoxia dynamics reduced Spot growth over the summer by 6–18% in these years relative to growth under constant good DO conditions. This approach can be used to evaluate impacts of observed or modeled scenarios of water quality dynamics on growth of juvenile Spot and serves as a template for development of predictive growth models for other species.

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Structure, Function, and Regulation of Insulin‐like Growth Factors in Fish

Cited by 26 publications

References 35 publications

Endocrine Biomarkers of Growth and Applications to Aquaculture: A Minireview of Growth Hormone, Insulin‐Like Growth Factor (IGF)‐I, and IGF‐Binding Proteins as Potential Growth Indicators in Fish

Endocrine Biomarkers of Growth and Applications to Aquaculture: A Minireview of Growth Hormone, Insulin‐Like Growth Factor (IGF)‐I, and IGF‐Binding Proteins as Potential Growth Indicators in Fish

The IGF/IGFBP system in rainbow trout (Oncorhynchus mykiss) adipose tissue: expression related to regional localization and cell type

Development and Field Application of a Model Predicting Effects of Episodic Hypoxia on Short‐Term Growth of Spot

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