Structure–function–property–design interplay in biopolymers: Spider silk

Tokareva, Olena; Jacobsen, Matthew M.; Buehler, Markus J.; Wong, Joyce Y.; Kaplan, David L.

doi:10.1016/j.actbio.2013.08.020

Cited by 213 publications

(244 citation statements)

References 108 publications

(190 reference statements)

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“…Despite its clear potential, it is extremely difficult to obtain silk from spiders [56], and substantial research effort has been spent to produce spider-like silk at commercial scales using biomimetic approaches. While the properties of spider silk have not yet matched, the use of scalable techniques, advances in understanding of the structure and natural spinning of native silks and improvements in protein expression, have been driving the field closer to its goals [57][58][59][60].…”

Section: Spider Silk Fibers: a Leap In Materials Tribologymentioning

confidence: 99%

Advances in Bio-inspired Tribology for Engineering Applications

Siddaiah

Menezes

2016

J Bio Tribo Corros

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Bio-inspired tribology is an interdisciplinary field of science where scientists and engineers seek to investigate and incorporate tribological properties encountered in biological beings into engineering applications. In this paper, bio-inspired tribological research that are speculated to have a huge impact on tribological applications have been reviewed. These research involve (1) investigations related to replication of lubricin found in synovial fluids of mammalian joints which have super-low friction values that can be utilized in IC engines, (2) surface replication concerning to superhydrophobic properties of gecko skin which is seen to have anti-wetting and selfcleaning properties, (3) friction-reducing shark skin through specialized nanoparticle coatings that is seen to give a different perspective on surface texturing, (4) new techniques, such as soft lithography to replicate surfaces of lotus leaf and air lubrication phenomenon inspired by emperor penguins that is being applied to propel boats, ships, and torpedoes faster by reducing skin friction underwater. Further, an investigation in self-healing materials inspired from pitcher plant that has led to the innovation of self-healing and slippery liquid-infused porous surfaces has been discussed. These research works reviewed not only provide a deep insight into the current advances in bio-inspired tribology but also helps understand the plausibility of the research applications in the future and the practicality of innovations possible.

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Section: Spider Silk Fibers: a Leap In Materials Tribologymentioning

confidence: 99%

Advances in Bio-inspired Tribology for Engineering Applications

Siddaiah

Menezes

2016

J Bio Tribo Corros

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“…48 The improved understanding of structure-function relationships over the last five years is likely to allow more rational and quantitative design to produce tunable, high-performance synthetic silks. 8,49 III. NATURAL SPIDER SILK PRODUCTION Spider silks are produced in vivo through a combination of chemistry to produce a liquid crystalline "aquamelt" spinning dope 50 and a series of predominantly mechanical steps to induce restructuring, alignment, and phase separation processes during spinning.…”

Section: Properties Of Spider Silkmentioning

confidence: 99%

“…While we have not yet matched the properties of spider silk using scalable techniques, advances in our understanding of the structure and natural spinning of native silks, and improvements in protein expression, are driving the field closer to its goals. [6][7][8][9] …”

Section: Introductionmentioning

confidence: 99%

With great structure comes great functionality: Understanding and emulating spider silk

et al. 2014

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The overarching aim of biomimetic approaches to materials synthesis is to mimic simultaneously the structure and function of a natural material, in such a way that these functional properties can be systematically tailored and optimized. In the case of synthetic spider silk fibers, to date functionalities have largely focused on mechanical properties. A rapidly expanding body of literature documents this work, building on the emerging knowledge of structure-function relationships in native spider silks, and the spinning processes used to create them. Here, we describe some of the benchmark achievements reported until now, with a focus on the last five years. Progress in protein synthesis, notably the expression on full-size spidroins, has driven substantial improvements in synthetic spider silk performance. Spinning technology, however, lags behind and is a major limiting factor in biomimetic production. We also discuss applications for synthetic silk that primarily capitalize on its nonmechanical attributes, and that exploit the remarkable range of structures that can be formed from a synthetic silk feedstock.

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“…A remarkable feature of natural silk is its outstanding toughness, which is superior to that of any of other artificial fiber (Liu et al, 2005;Keten et al, 2010;Omenetto and Kaplan, 2010;Porter et al, 2013;Tokareva et al, 2014). Most researchers believe that the toughness of silk originates from the combined action of the alternating hydrophobic and hydrophilic pattern in the protein primary sequence and the unique spinning process used to prepare the silk fibers.…”

Section: Introductionmentioning

confidence: 99%

Development of New Smart Materials and Spinning Systems Inspired by Natural Silks and Their Applications

Cheng

Lee

2016

Front. Mater.

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Silks produced by spiders and silkworms are charming natural biological materials with highly optimized hierarchical structures and outstanding physicomechanical properties. The superior performance of silks relies on the integration of a unique protein sequence, a distinctive spinning process, and complex hierarchical structures. Silks have been prepared to form a variety of morphologies and are widely used in diverse applications, for example, in the textile industry, as drug delivery vehicles, and as tissue engineering scaffolds. This review presents an overview of the organization of natural silks, in which chemical and physical functions are optimized, as well as a range of new materials inspired by the desire to mimic natural silk structure and synthesis.

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Structure–function–property–design interplay in biopolymers: Spider silk

Cited by 213 publications

References 108 publications

Advances in Bio-inspired Tribology for Engineering Applications

Advances in Bio-inspired Tribology for Engineering Applications

With great structure comes great functionality: Understanding and emulating spider silk

Development of New Smart Materials and Spinning Systems Inspired by Natural Silks and Their Applications

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