Structure-Function Studies of the Voltage-Dependent Calcium Channels

Križanová, Oľga; Lory, Philippe; Schwartz, Arnold

doi:10.1007/978-94-011-1725-8_1

Cited by 6 publications

(5 citation statements)

References 19 publications

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“…Nevertheless, these slight differences can also argue for the existence of a structurally distinct form of HVA Ca 2+ channel as has been suggested previously (Nargeot etal, 1992;Perez-Reyes & Schneider, 1994Krizanova, 1996). Rat brain Ca 2+ channel al-subunit (rbE-II), which is structurally related to HVA class A and B (Soong et ah, 1993), displayed many properties of the LVA Ca 2+ channels (Soong et al, 1993).…”

Section: Pharmacological Propertiesmentioning

confidence: 80%

Voltage-gated calcium channels inPleurodelesoocytes: classification, modulation and functional roles

Ouadid-Ahidouch¹

1998

Zygote

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In unfertilised Pleurodeles foocytes, two distinct types of high voltage-activated Ca 2+ channels are expressed: a slowly inactivating Ca 2+ channel and a transient one. The first is dihydropyridinesensitive and is referred to as the L-type Ca 2+ channel. The transient channel is highly sensitive to Ni 2+ . Phosphorylation through protein kinases G and A facilitates and inhibits the L-type Ca 2+ channel respectively. The transient type channel is insensitive to stimulation by protein kinases (A and G). The functional expression of L-type and transient Ca 2+ channels is modulated by the two maturation seasons. The transient Ca 2+ currents are only observed during the resting season, while the L-type current is observed either alone during the breeding season or in association with the transient current during the resting season. Moreover, the current density of the L-type Ca 2+ channel is much greater during the breeding season than the resting season. Thus, the wide distribution of L-type Ca 2+ channels in Pleurodeles oocytes during the two seasons suggests that the roles of these channels may be important in the regulation of the maturation process.

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Section: Pharmacological Propertiesmentioning

confidence: 80%

Voltage-gated calcium channels inPleurodelesoocytes: classification, modulation and functional roles

Ouadid-Ahidouch¹

1998

Zygote

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“…Four types of voltage dependent Ca 2þ channels with specific functions and location has been identified. These include (1) L-type, located in skeletal, cardiac and smooth muscle cells, (2) T-type, located in pacemakers' cells, (3) N-type, found in neuronal cells and (4) P-type, located in neuromuscular junction [29,30].…”

Section: Pharmacological Profilementioning

confidence: 99%

“…Out of which, only four 1,5-benzothiazepines are in therapeutic use for their coronary vasodilators, calcium antagonists (Diltiazem 2, Clentiazem, 3) and as antidepressant (e.g. Thiazesim 4, Quetiapine fumarate, 5) [29] activities. The wide range of pharmacological profile shown by 1,5-benzothiazepine can be classified into the following categories.…”

Section: Pharmacological Profilementioning

confidence: 99%

1,5-Benzothiazepine, a versatile pharmacophore: A review

Bariwal

Upadhyay

Manvar

et al. 2008

European Journal of Medicinal Chemistry

187

109

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“…The major entry pathway of calcium into cardiac cells is assumed to be via voltage-activated calcium channels (VACC). The electrophysiological properties of these channels have been extensively characterized in terms of their voltage dependence, inactivation, single-channel conductance, and pharmacology, such that several types of channels (named L, N, P/Q, R, and T) have been identified (10,20,25). Subsequent biochemical and molecular biology studies have established the structure of these channels as multi-subunit complexes composed of an ion-conducting ␣ 1 -subunit protein associated with ␣ 2 -, ␤-, ␥-, and ␦-regulatory subunits.…”

mentioning

confidence: 99%

Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes

Pignier

Potreau

2000

American Journal of Physiology-Heart and Circulatory Physiology

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Calcium current was recorded from ventricular cardiomyocytes of rats at various stages of postnatal development using the whole cell patch-clamp technique. In cultured 3-day-old neonatal cells, the current carried by Ca(2+) or Ba(2+) (5 mM) was not completely inhibited by 2 microM nifedipine. A residual current was activated in the same voltage range as the L-type, nifedipine-sensitive Ca(2+) current, but its steady-state inactivation was negatively shifted by 16 mV. This nifedipine-resistant calcium current was not further inhibited by other organic calcium current antagonists such as PN200-110, verapamil, and diltiazem nor by nickel, omega-conotoxin, or tetrodotoxin. It was completely blocked by cadmium and increased by isoproterenol and forskolin. This current was >20% of total calcium current in ventricular myocytes freshly isolated from neonatal rats, and it decreased during postnatal maturation, disappearing at the adult stage. This suggests that this current could be caused by an isoform of the L-type calcium channel expressed in a way that reflects the developmental stage of the rat heart.

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Structure-Function Studies of the Voltage-Dependent Calcium Channels

Cited by 6 publications

References 19 publications

Voltage-gated calcium channels inPleurodelesoocytes: classification, modulation and functional roles

Voltage-gated calcium channels inPleurodelesoocytes: classification, modulation and functional roles

1,5-Benzothiazepine, a versatile pharmacophore: A review

Characterization of nifedipine-resistant calcium current in neonatal rat ventricular cardiomyocytes

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