Structure‐Functions Relationship of Modified Starches for Pharmaceutical and Biomedical Applications

Labelle, Marc‐André; Ispas‐Szabo, Pompilia; Mateescu, Mircea Alexandru

doi:10.1002/star.202000002

Cited by 29 publications

(15 citation statements)

References 118 publications

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“…For starch materials, the hydroxylic groups play an important role by their involvement in hydrogen associations and in the stabilization of polysaccharidic chains that can adopt various conformations, depending on various parameters (i.e., starch origin, water molecules present in the structure, etc.) [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Design of Catalase Monolithic Tablets for Intestinal Targeted Delivery

2021

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Several studies confirmed a correlation between elevated hydrogen peroxide (H2O2) levels in patients with intestinal bowel diseases (IBD) and the negative effects caused by its presence. The objective of this study was to explore the potential use of catalase (CAT) to diminish the level of H2O2 and its deleterious action on intestinal mucosa. Oral dosage forms of a CAT bioactive agent targeted to the intestines were designed and tested in various simulated gastric and intestinal media. Monolithic tablets (30% loading) were prepared using commercial CarboxyMethylCellulose (CMC) or synthesized CarboxyMethylStarch (CMS) and TriMethylAmineCarboxyMethylStarch (TMACMS) as matrix-forming excipients. For starch derivatives, the presence of the ionic groups (carboxymethyl and trimethylamine) was validated by spectral analysis. In vitro studies have shown that tablets formulated with TMACMS and 30% CAT resisted the acidity of the simulated gastric fluid and gradually released the enzyme into the simulated intestinal fluid. The investigation of the CAT release mechanism revealed the role of anionic and cationic groups of polymeric excipients and their involvement in the modulation of the CAT dissolution profile. The proposed drug delivery system can be considered an efficient solution to target CAT release in the intestine and contribute to the reduction of H2O2 associated with intestinal inflammation.

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Section: Resultsmentioning

confidence: 99%

Design of Catalase Monolithic Tablets for Intestinal Targeted Delivery

2021

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“…[ 38 ] The production of increased quantities of short AM and AP molecules upon de‐branching by PUL provides greater molecular alignment and aggregation golden opportunities. [ 39 ] It must be noted at this stage that de‐branched starch is obtained by modification with PUL, it selectively act on α‐1,6 bonds, [ 40 ] and there are two types of PUL. PUL type 1 attacks the α‐1,6 linkages, thereby releasing the AP branch chains.…”

Section: Synthesis and Properties Of Triple Modified Starchesmentioning

confidence: 99%

The Recent Development in the Syntheses, Properties, and Applications of Triple Modification of Various Starches

Ashogbon

2021

Starch Stärke

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The problems associated with native starches, single and dual modifications of various starches are stated in order to justify the utilization of triple modification of various starches. In triple modification, the first and dual modifications prepare the starch chains, structures, and polymeric components of the starch granules for the acceptance and accommodation of the triple modification. Sometimes there is development of pores, cracks, and other morphological flaws or weakening of the starch structures and chains during the first and dual modifications in order for easy penetration of the modifying agents during the third modification. There are mainly two types of triple modification, that is, homogeneous and heterogeneous. Homogeneous triple modification is when all the three stages of the process are similar, for example, acetylation/oxidation/crosslinking, this is homogeneous triple chemical modification. An example of homogeneous triple physical modification is a combination of extrusion/ultrasonication/ANN. When three enzymes (α‐amylase/transglucosidase/pullulanase) are involved in the stages of the process, it is called homogeneous triple enzymes modification. In contrast, heterogeneous triple modification involves combinations of the various three stages that constitute the process, for example, extrusion/pullulanase/ANN. This overview discusses the syntheses, properties, and utilization of triple modified starches.

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“…The differences in characteristics such as granule shape and size, amylose content, and crystallinity type, among others, contribute to variations in the functional properties of each starch. Further modification of native starch by physical, chemical, or enzymatical techniques alters the structure and physicochemical properties and, in turn, yields modified starches with broadened functional properties and applications [ 5 , 6 ]. Modified starches are now commonly found not only as ingredients in foods [ 7 , 8 ], but also as compositions or additives in cosmetics [ 9 , 10 ] and excipients in pharmaceuticals [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Functional Properties of Modified KJ CMU-107 Rice Starches as Pharmaceutical Excipients

Kittipongpatana

2022

Polymers

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Starch extracted from KJ CMU-107 rice, with amylose content of 13.4%, was modified to yield pre-gelatinized starch (PGS), carboxymethyl starch (CMS), crosslinked carboxymethyl starch (CLCMS), crosslinked starch (CLS), and hydroxypropyl starch (HPS). Their physicochemical properties were assessed in comparison with the native starch (NS), and their functional properties were then evaluated for potential use as pharmaceutical excipients. Scanning electron microscopic (SEM) images and X-ray diffraction (XRD) patterns showed that granules of all but one of the modified starches retained the native character and crystalline arrangement. The exception, PGS, exhibited extensive granular rupture, which correlated with the loss of crystallinity suggested by the amorphous halo in XRD. Energy-dispersive X-ray (EDX) data confirmed the modification by the presence of related elements. Carboxymethylation increased solubility in unheated water, while crosslinking improved swelling. All modified starches displayed improved oil absorption capacity by 17–64%, while CMS and CLCMS also exhibited significant moisture sorption at above 75% RH PGS and HPS exhibited lower gelatinization temperature (Tg) and enthalpic change (ΔH), while CLS showed higher Tg and ΔH. CMS, CLCMS, and CLS showed adequate powder flow and compactibility, qualifying as potential tablet excipients. The 5% w/v solutions of CMS, CLMS, and HPS also formed intact films with suitable tensile strength. Overall, modified starches derived from KJ CMU-107 could potentially be developed into new pharmaceutical excipients.

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Structure‐Functions Relationship of Modified Starches for Pharmaceutical and Biomedical Applications

Cited by 29 publications

References 118 publications

Design of Catalase Monolithic Tablets for Intestinal Targeted Delivery

Design of Catalase Monolithic Tablets for Intestinal Targeted Delivery

The Recent Development in the Syntheses, Properties, and Applications of Triple Modification of Various Starches

Physicochemical and Functional Properties of Modified KJ CMU-107 Rice Starches as Pharmaceutical Excipients

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