Structure, magnetic properties, catalase activity and DFT studies of [Mn2(μ-RCOO)2(μ-OR)2]2+ type dinuclear manganese(III,III) complexes

Biju, A.; Rajasekharan, M. V.

doi:10.1016/j.ica.2011.03.004

Cited by 7 publications

(4 citation statements)

References 65 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[8][9][10][11] Because of their potential use as catalytic scavengers of H 2 O 2 against oxidative stress, several mono-and dinuclear complexes involving different types of ligands have been synthesized and characterized in an attempt to mimic the active sites and catalytic activities of enzymes. [12][13][14][15][16][17][18][19] While numerous Mn complexes have been synthesized, few systematic studies have explored the effect of the N-N chelating coordination of neutral bipy and phen ligands on catalase and biological activity. [20][21][22] To investigate the catalase and antimicrobial activities of complexes in this class, we synthesized five * For correspondence (4) and Mn(phen) 2 (ba)(H 2 O)](ClO 4 )(CH 3 OH) (5), where bipy = 2,2 -bipyridine, phen = 1,10-phenanthroline, and ba = benzoic acid.…”

Section: Introductionmentioning

confidence: 99%

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

2016

View full text Add to dashboard Cite

Five mononuclear Mn(II) complexes, [Mn(phen) 2 (ClO 4) 2 ] (1), [Mn(phen) 3 ](ClO 4) 2 (H 2 CO 3) 2 (2), [Mn(bipy) 2 (ClO 4) 2 ] (3), [Mn(bipy) 3 ](ClO 4) 2) (4), and Mn(phen) 2 (ba)(H 2 O)](ClO 4)(CH 3 OH) (5), where bipy = 2,2'-bipyridine, phen = 1,10-phenanthroline, and ba = benzoic acid were prepared and characterized by Xray, IR and UV-Vis spectroscopies, and their catalase-like and biological activities were studied. The presence of two different types and the number of chelating NN-donor neutral ligands allowed for analysis of their effects on the catalase and biological activities. It was observed that the presence and number of phen ligands improved the activity more than the bipy ligand. Complexes 1 and 2, which contain more basic phen ligands, disproportionate H 2 O 2 faster than complexes 3 and 4, which contain less basic bipy ligands. The in vitro antimicrobial activities of all the complexes were also tested against seven bacterial strains by microdilution tests. All the bacterial isolates demonstrated sensitivity to the complexes and the antifungal (anticandidal) activities of the Mn(II) complexes were remarkably higher than the reference drug ketoconazole.

show abstract

Section: Introductionmentioning

confidence: 99%

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

2016

View full text Add to dashboard Cite

show abstract

“…Following the first publication of the Mn(II) complexes possessing bipyridine (bipy) and phenanthroline (phen) ligands by Fukuda and Sone in 1970, a large number of such compounds with different metals using mainly the same ligands were synthesized and published (Fukuda and Sone, 1970;Bailey, et al, 1980;Paulovicova, et al, 2001;Madalan, et al, 2004). Because of Mn compounds' potential use as catalytic scavengers of H 2 O 2 against oxidative stress, several mono-and binuclear inorganic compounds with various ligands were obtained and characterized in an effort to mimic the active sites of enzymes (Triller, et al, 2002;Reddig, et al, 2004;Wu, et al, 2004;Signorella, et al, 2007;Biava, et al, 2009;Biju and Rajasekharan, 2011;Vazquez-Fernandez, et al, 2011;Signorella and Hureau, 2012).…”

Section: Introductionmentioning

confidence: 99%

Can Mn coordination compounds be good candidates for medical applications?

Kozieł,

Wojtala,

Szmitka

et al. 2024

Front. Chem. Biol.

View full text Add to dashboard Cite

Metal centres provide unique foci for varied biological modes of action that often but not exclusively involve redox or metal-ligand reactions. Metal complexes offer alternative and flexible coordination geometries, electron and proton transfer sites, inner and outer sphere reactivities, sites for redox-active, hemi-labile, and non-innocent ligands, and a variety of potentially controllable properties for exploitation in a therapeutic or biological context. The discovery of the first anticancer, the metal-based compound cisplatin in 1965 by Barnett Rosenberg was a historical outstanding breakthrough and led to a new area of metal-drug discovery. Some metal-based compounds have FDA approval for clinical use, while some undergo clinical trials for various medical therapies. This mini-review focuses on recent progress on Mn-based complexes with potential anticancer, antibacterial, and antifungal activities.

show abstract

“…The use of transition metal complexes as antimicrobial agents, and for their potential applications as inorganic pharmaceuticals and in medicine for diagnostics, has gained great interest from researchers [1][2][3][4]. In this regard, large and rising numbers of mono-and polynuclear complexes of different metals, and with different classes of chelating ligands involving Schiff bases, bipyridine, and phenanthroline with different anions, were presented in literature [5][6][7][8][9][10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

“…Of transition metals, manganese is considered an essential micronutrient in living organisms and has an important role in a broad range of enzyme-catalyzed reactions. There is no doubt about the potential use of Mn(II) complexes as catalytic scavengers for H 2 O 2 against oxidative stress [7][8][9][10][11][12][13][14][15]. From this point of view, an increasing interest with the synthesis of more Mn(II) complexes in order to investigate their catalytic and antimicrobial activities.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, X-ray Structure, Hirshfeld Analysis of Biologically Active Mn(II) Pincer Complexes Based on s-Triazine Ligands

2020

View full text Add to dashboard Cite

Herein, the synthesis and antimicrobial activities of [Mn(MorphBPT)(H2O)2NO3]NO3; (1) and [Mn(PipBPT)(H2O)2NO3]NO3; (2) complexes of the pincer-type tridentate ligands MorphBPT; 4-(4,6-di(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine and PipBPT; 2-(piperidin-1-yl)-4,6-di(1H-pyrazol-1-yl)-1,3,5-triazine are presented. Both complexes have slightly distorted octahedral coordination geometry. Their molecular packing depends on O–H···O, C–H···O hydrogen bonds and anion–π stacking contacts. Hirshfeld analysis was used to quantify the different contacts. Both complexes exhibited better anti-fungal activity than the standard Fluconazole and comparable antibacterial activity to Gentamycin against Staphylococcus aureus and Escherichia coli microbes. Moreover, complexes 1 and 2 are biologically more active than the free ligands against these microbes.

show abstract

Structure, magnetic properties, catalase activity and DFT studies of [Mn2(μ-RCOO)2(μ-OR)2]2+ type dinuclear manganese(III,III) complexes

Cited by 7 publications

References 65 publications

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

Mn(II) complexes with bipyridine, phenanthroline and benzoic acid: Biological and catalase-like activity

Can Mn coordination compounds be good candidates for medical applications?

Synthesis, X-ray Structure, Hirshfeld Analysis of Biologically Active Mn(II) Pincer Complexes Based on s-Triazine Ligands

Contact Info

Product

Resources

About