The overuse of fossil fuels has caused a serious energy crisis and environmental pollution. Due to these challenges, the search for alternative energy sources that can replace fossil fuels is necessary. Hydrogen is a widely acknowledged future energy carrier because of its nonpolluting properties and high energy density. To realize a hydrogen economy in the future, it is essential to construct a comprehensive hydrogen supply chain that can make hydrogen a key energy carrier. This paper reviews the various technologies involved in the hydrogen supply chain, encompassing hydrogen production, storage, transportation, and utilization technologies. Then, the challenges of constructing a hydrogen supply chain are discussed from techno-economic, social, and policy perspectives, and prospects for the future development of a hydrogen supply chain are presented in light of these challenges.