Structure of 9-(2-hydroxyethyl)guanine

Shibata, Manabu; Takénaka, Akio; Sasada, Y.

doi:10.1107/s0108270185008319

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…The second G:G P pair involves N2±H ¼ N3 P and N2 P ±H P¼ N3 hydrogen bonds between the minor groove sites. These two base pairs are of the same types as those reported in several X-ray structures (7,42,43). The third A:A P pair involves the two N6±H ¼ N7 hydrogen bonds between major sites.…”

Section: Base-pair Formationsupporting

confidence: 58%

Crystal structure of d(GCGAAAGCT) containing parallel-stranded duplex with homo base pairs and anti-parallel duplex with Watson-Crick base pairs

Sunami

Kobuna²,

Kondo³

et al. 2002

Nucleic Acids Symposium Series

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A DNA fragment d(GCGAAAGCT), known to adopt a stable mini-hairpin structure in solution, has been crystallized in the space group I4 1 22 with the unitcell dimensions a = b = 53.4 A Ê and c = 54.0 A Ê , and the crystal structure has been determined at 2.5 A Ê resolution. The four nucleotide residues CGAA of the ®rst half of the oligomer form a parallel duplex with another half through the homo base pairs, C 2 :C 2 + (singly-protonated between the Watson± Crick sites), G 3 :G 3 (between the minor groove sites), A 4 :A 4 (between the major groove sites) and A 5 :A 5 (between the Watson±Crick sites). The two strands remaining in the half of the parallel duplex are split away in different directions, and they pair in an anti-parallel B-form duplex with the second half extending from a neighboring parallel duplex, so that an in®nite column is formed in a head-to-tail fashion along the c-axis. It seems that a hexaammine cobalt cation supports such a branched and bent conformation of the oligomer. One end of the parallel duplex is stacked on the corresponding end of the adjacent parallel duplex; between them, the guanine base of the ®rst residue is stacked on the fourth ribose of another duplex.

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Section: Base-pair Formationsupporting

confidence: 58%