Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter

Structural elucidation of HIV-1 G-quadruplexes in a cellular environment and their ligand binding using responsive 19F-labeled nucleoside probes

“…1A). 11–13 Notably, LTR-III and LTR-IV form GQs in vitro in a mutually exclusive manner. While LTR-III adopts a unique architecture made of a hybrid-type GQ juxtaposed with a three G-C paired hairpin motif, LTR-IV attains a parallel GQ topology with a T-bulge (Fig.…”