The study of flat plate and airfoil wakes is important in the fields of drag reduction, staged axial fans/compressors and acoustics among others. The focus of this research is the influence of the simulation domain and turbulence models on the accuracy of the numerical results when compared to experimental data. The results have shown that the selection of the simulation domain and turbulence model depends highly on the intended application and time requirements. For quick, near-wake averaged quantities, the k-ε model is recommended. For studying far wake-averaged results, the Reynolds Stress model is superior over the k-ε model. While if a time dependant solution is of necessity, LES is the desired option. However, LES does require the airfoil geometry to be included in the domain because it performs poorly when given only inlet velocities, turbulence kinetic energy and eddy dissipation at the trailing edge of the airfoil.