Structure of Airway Smooth Muscle and Its Innervation

Gabella, Giorgio

doi:10.1007/978-1-4613-0779-2_1

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…Airway caliber can be adjusted through bronchomotor tone and fluid secretion and accumulation in the short term. Central nervous control, via the vagus nerve, dominates as a parasympathetic control acting to constrict bronchial smooth muscle (Gabella 1989). Bronchodilatory responses result from sparse sympathetic innervations and circulating catecholamines and possibly nonadrenergic noncholinergic systems (NANC) (Widdicombe 1989).…”

Section: Discussionmentioning

confidence: 99%

Exercise-induced respiratory resistance changes as measured with the airflow perturbation device

Silverman¹,

Johnson²,

Scott³

et al. 2004

Physiol. Meas.

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Respiratory resistance (Rrs) changes during physical labor can modify the work of breathing and thus influence the time that the labor can be performed. Ideal in vivo human respiratory performance measurements should have fine temporal resolution and minimally impact the respiratory system itself. The airflow perturbation device (APD) provides respiratory resistance measurements in this manner. Pre-exercise Rrs was compared with post-exercise Rrs, continuously monitored for 6 min in 12 non-asthmatic subjects. Rrs following exercise at 70-75% VO2max was below pre-exercise levels for 40 s into recovery (p < 0.05) and inhalation resistance differed more markedly than exhalation resistance. The same post-exercise Rrs decline was found when Rrs measurements were compared to those taken during flow rates comparable to those found late in recovery. Results indicate that (1) Rrs indeed declines following exercise in non-asthmatic subjects, probably due to bronchial dilation, (2) Rrs changes can occur on short time scales, (3) Rrs changes are not related primarily to flow rate.

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Section: Discussionmentioning

confidence: 99%

Exercise-induced respiratory resistance changes as measured with the airflow perturbation device

Silverman¹,

Johnson²,

Scott³

et al. 2004

Physiol. Meas.

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“…Because the total volume of sartion occurred to sites of muscarinic receptor-evoked colemma in porcine trachealis muscle cells must be a PLC activation in or near the sarcolemma. That the fraction of the total volume of cytosol (Gabella, 1989), membrane target of translocated PLCb 2 in SARC was, the content of PLCb 2 per unit volume of SARC is likely in fact, the sarcolemma is supported by characteristics to be many-fold that of cytosol. The high ratio of PLCb 2 of the SARC fraction, discussed above.…”

mentioning

confidence: 97%

Smooth muscle sarcolemma-associated phospholipase C-β2; agonist-evoked translocation

et al. 1997

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About 25% of the total cellular PLC beta 2 content was found to be associated with a sarcolemmal fraction (SARC) isolated from unstimulated porcine trachealis smooth muscle. SARC-associated PLC beta 2 was located within two compartments, a detergent-extractable compartment and a nondetergent extractable compartment. SARC PLC beta 2 was measured after extraction with 0.6 M KCI; therefore, PLC beta 2 was not bound solely by electrostatic forces within either of these compartments. PLC beta 2 was shown to translocate from cytosol to SARC during a 20-sec activation of intact muscle with a muscarinic agonist, carbachol (CARB); i.e., cytosolic total PLC beta 2 content decreased significantly to 73 +/- 7% of control and SARC total PLC beta 2 content increased to 180 +/- 15% of control value. This translocation was maintained at 5 min of CARB. CARB-evoked translocation occurred into the detergent-extractable SARC fraction, and PLC beta 2 content in this fraction increased 300% compared with that in unstimulated muscle. After CARB, SARC PLC beta 2 content accounted for > 50% of total cellular PLC beta 2 content. CARB-evoked increase in PLC activity in SARC paralleled the increase in PLC beta 2 content. CARB-induced translocations of PLC beta 2 from the cytosol to SARC were of a similar magnitude as occurred with phorbol ester-induced translocations of PKC alpha.

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Anatomy of Airways Smooth Muscle

Gabella

1994

Airways Smooth Muscle

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Structure of Airway Smooth Muscle and Its Innervation

Cited by 3 publications

References 56 publications

Exercise-induced respiratory resistance changes as measured with the airflow perturbation device

Exercise-induced respiratory resistance changes as measured with the airflow perturbation device

Smooth muscle sarcolemma-associated phospholipase C-β2; agonist-evoked translocation

Anatomy of Airways Smooth Muscle

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