1998
DOI: 10.1046/j.1469-7580.1998.19240573.x
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Structure of chordae tendineae in the left ventricle of the human heart

Abstract: The bicuspid (mitral) valve complex of the human heart consists of functional units which include the valve leaflets, chordae tendineae and the papillary muscles. The mechanical properties of these functional units depend to a large extent on the link between the muscle and the valve. This link is usually arranged in a branching network of avascular tendinous chordae composed of collagen and elastic fibres, which transmit contractions of the papillary muscle to the valve leaflets. In order to perform t… Show more

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Cited by 96 publications
(102 citation statements)
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“…This structure was consistent with that reported previously. 1 Tenomodulin was restricted to the elastin-rich mid layer ( Figure 2C) and was not detected in the other layers. The normal CTC showed no expression of chondromodulin-I ( Figure 2D) or VEGF-A ( Figure 2F), and there was no abnormal vessel formation.…”
Section: Expression Of Tenomodulin In Normal Ctcmentioning
confidence: 99%
See 1 more Smart Citation
“…This structure was consistent with that reported previously. 1 Tenomodulin was restricted to the elastin-rich mid layer ( Figure 2C) and was not detected in the other layers. The normal CTC showed no expression of chondromodulin-I ( Figure 2D) or VEGF-A ( Figure 2F), and there was no abnormal vessel formation.…”
Section: Expression Of Tenomodulin In Normal Ctcmentioning
confidence: 99%
“…1 This avascularity is abrogated in several valvular heart diseases (VHDs). [2][3][4] Chondromodulin-I, which is an antiangiogenic factor isolated from bovine cartilage, [5][6][7][8] is also expressed in the eye and is critically involved in the maintenance.…”
mentioning
confidence: 99%
“…The essential framework of the chordae tendineae is constituted by a central core of crimped collagen fibres covered by elastic fibres and both are enveloped by endothelium (Millington-Sanders et al 1998). This microstructure provides the mechanical response that is typical of collagenous tissues.…”
Section: (I) the Leafletsmentioning
confidence: 99%
“…Although the onset of aortic valve stenosis has been reported in Smad6-deficient mice (14), in fibulin 4-deficient mice (15), and in humans with the NOTCH1 mutation (16), the abnormality has primarily been observed during cardiac valve development. As avascular tissues, the cardiac valve complex and cartilage share common structural properties (17,18). The cartilage and tendons are known to have unique angioinhibitory mechanisms (19), disruption of which results in angiogenesis and destruction of the joint, leading to arthritis (20).…”
Section: Introductionmentioning
confidence: 99%