Structure of Coxsackievirus A16 in complex with GPP3

Colibus, Luigi De; Wang, X.; Tijsma, Aloys; Neyts, Johan; Spyrou, John A. B.; Ren, Jingshan; Grimes, J.M.; Puerstinger, Gerhard; Leyssen, Pieter; Fry, Elizabeth E.; Rao, Z.; Stuart, D.I.

doi:10.2210/pdb5abj/pdb

2015

DOI: 10.2210/pdb5abj/pdb

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Structure of Coxsackievirus A16 in complex with GPP3

Luigi De Colibus¹,

X. Wang²,

Aloys Tijsma³

et al.

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The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry

Kuo

Corona

Fanunza

et al. 2021

Viruses

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Ebola virus (EBOV), one of the most infectious human viruses and a leading cause of viral hemorrhagic fever, imposes a potential public health threat with several recent outbreaks. Despite the difficulties associated with working with this pathogen in biosafety level-4 containment, a protective vaccine and antiviral therapeutic were recently approved. However, the high mortality rate of EBOV infection underscores the necessity to continuously identify novel antiviral strategies to help expand the scope of prophylaxis/therapeutic management against future outbreaks. This includes identifying antiviral agents that target EBOV entry, which could improve the management of EBOV infection. Herein, using EBOV glycoprotein (GP)-pseudotyped particles, we screened a panel of natural medicinal extracts, and identified the methanolic extract of Perilla frutescens (PFME) as a robust inhibitor of EBOV entry. We show that PFME dose-dependently impeded EBOV GP-mediated infection at non-cytotoxic concentrations, and exerted the most significant antiviral activity when both the extract and the pseudoparticles are concurrently present on the host cells. Specifically, we demonstrate that PFME could block viral attachment and neutralize the cell-free viral particles. Our results, therefore, identified PFME as a potent inhibitor of EBOV entry, which merits further evaluation for development as a therapeutic strategy against EBOV infection.

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The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry

Kuo

Corona

Fanunza

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

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Structure of Coxsackievirus A16 in complex with GPP3

Cited by 1 publication

References 0 publications

The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry

The Methanolic Extract of Perilla frutescens Robustly Restricts Ebola Virus Glycoprotein-Mediated Entry

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