Structure of diacetate-bis (picolimamide)-diaqua cobalt(II), [Co(H2O)2 (C5H4NC(O)NH2)2] (CH3COO)2�4H2O

Bis(N‐picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

“…The crystal structures confirm that the two picolinamide ligands coordinate through the pyridyl nitrogen and amide oxygen, acting as neutral N,O ligand. [ 36 , 37 , 40 ] The axial isothiocyanato ligands coordinate to the Co(II) center through the nitrogen atom, as opposed to through the sulfur atom, and this result is consistent with the previous complexes and DFT calculations performed by Đaković and co‐workers. [40] …”

“…The Co−N(pyridyl) bond lengths are in the range 2.0887(18)–2.141(3) Å and the Co−O(amide) bond lengths are in the range 2.0934(17)–2.230(4) Å. This is consistent with related high spin (HS) Co(II) compounds which have reported to have Co−N(pyridyl) bond lengths of 2.07–2.12 Å and Co−O(amide) bond lengths of 2.06–2.12 Å [36,37,40] . All complexes show a distorted octahedral geometry around the central Cot(II) center, with the relevant bond angles in the range 75.90(12)–99.52(14)°, deviating from the ideal 90° (Table S3).…”

“…On changing the ancillary diisothiocyanato ligands to either dichlorido ( 9 ) or di‐aqua ( 10 ), single orange crystals were obtained, with structural solutions performed in a monoclinic ( P 2 1 / c ) cell. The crystal structures confirm that the two picolinamide ligands coordinate through the pyridyl nitrogen and amide oxygen, acting as neutral N,O ligand [36,37,40] . The axial isothiocyanato ligands coordinate to the Co(II) center through the nitrogen atom, as opposed to through the sulfur atom, and this result is consistent with the previous complexes and DFT calculations performed by Đaković and co‐workers [40] …”

“…To date, the antifungal properties of bis( N ‐picolinamido)cobalt(II) complexes have not yet been investigated, with previous literature only reporting the structural compositions of the complexes. The first study, in 1984, was conducted by Tsintsadze and co‐workers on [(L) 2 Co(H 2 O) 2 ][(CH 3 COO) 2 ] (Figure 1G, L=C 5 H 4 NC(O)NH 2 ), in which they investigated how the position of the amide group from the pyridine ring influences the structure of the corresponding metal complexes [36] . Structural data shows the dicationic octahedral Co(II) complex has two picolinamide ligands bound to the metal in a neutral N,O fashion, with two aqua ligands in a trans arrangement.…”

“…The first study, in 1984, was conducted by Tsintsadze and co‐workers on [(L) 2 Co(H 2 O) 2 ][(CH 3 COO) 2 ] (Figure 1 G, L=C 5 H 4 NC(O)NH 2 ), in which they investigated how the position of the amide group from the pyridine ring influences the structure of the corresponding metal complexes. [36] Structural data shows the dicationic octahedral Co(II) complex has two picolinamide ligands bound to the metal in a neutral N,O fashion, with two aqua ligands in a trans arrangement. Further studies with chloride or squarate acting as the counter‐ion confirmed this trans geometry.…”