Structure of glycine N-acyltransferase clarifies its catalytic mechanism

Abstract

Glycine N-acyltransferase (GLYAT; EC 2.3.1.13) is a key enzyme in mammalian homeostasis that has been linked to several pathologies in humans, including cancer. Here we report the first crystal structure of a member of the GLYAT family, and a detailed interpretation of its structure and enzymatic mechanism. This work will aid further studies on GLYAT and its involvement in metabolic diseases and cancer.