“…Medium-resolution NMR solution structures have been described for human EGF (Cooke et al, 1987;Hommel et al, 1992) and murine EGF (Montelione et al, 1986(Montelione et al, , 1987(Montelione et al, , 1992Kohda & Inagaki, 1992a, 1992b, and for several homologous proteins including hTGFa (Kline et al, 1990;Harvey et al, 1991;Moy et al, 1993) and the EGF-like domains from bovine coagulation factor X (Selander-Sunnerhagen et al, 1992; Energy refinement of mECF and hTGFa NMR structures Ullner et al, 1992), human factor 1X (Huang et al, 1991;Baron et al, 1992), human tissue-type plasminogen activator (Smith et al, 1994), and human urokinase-type plasminogen activator (Hansen et al, 1994). X-ray crystal structures of the EGF-like domains of human E-selectin (Graves et al, 1994;Weis, 1994) and human factor Xa (Padmanabhan et al, 1993) have also been determined recently.…”