Structure of neuro-endocrine and neuro-epithelial interactions in human foetal pancreas

Krivova, Yuliya; Proshchina, Alexandra; Barabanov, V. M.; Леонова, О.Г.; Saveliev, S. V.

doi:10.1016/j.tice.2016.10.005

Cited by 9 publications

(9 citation statements)

References 52 publications

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“…As in the gastrointestinal tract, labeled preganglionic vagal fibers innervate primarily cholinergic or nitrergic neurons located in small intrapancreatic ganglia 29, 30 , in a position to affect both endocrine and exocrine functions. Intrapancreatic ganglia are also found in mouse 31, 32 and human pancreas 33, 34 (Fig. 4).…”

Section: Introductionmentioning

confidence: 89%

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

Berthoud

Neuhuber

2019

Annals of the New York Academy of Sciences

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With few effective treatments available, the global rise of metabolic diseases, including obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease, seems unstoppable. Likely caused by an obesogenic environment interacting with genetic susceptibility, the pathophysiology of obesity and metabolic diseases is highly complex and involves crosstalk between many organs and systems, including the brain. The vagus nerve is in a key position to bidirectionally link several peripheral metabolic organs with the brain and is increasingly targeted for neuromodulation therapy to treat metabolic disease. Here, we review the basics of vagal functional anatomy and its implications for vagal neuromodulation therapies. We find that most existing vagal neuromodulation techniques either ignore or misinterpret the rich functional specificity of both vagal efferents and afferents as demonstrated by a large body of literature. This lack of specificity of manipulating vagal fibers is likely the reason for the relatively poor beneficial long-term effects of such therapies. For these therapies to become more effective, rigorous validation of all physiological endpoints and optimization of stimulation parameters as well as electrode placements will be necessary. However, given the large number of function-specific fibers in any vagal branch, genetically-guided neuromodulation techniques are more likely to succeed.

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Section: Introductionmentioning

confidence: 89%

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

Berthoud

Neuhuber

2019

Annals of the New York Academy of Sciences

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“…During the middle and late foetal periods, the nervous system components also contact epithelial cells located in ducts or in clusters outside the ductal epithelium and form complexes with separate epithelial cells. We observed CK19-positive cells inside the ganglia and nerve bundles, which were located separately or integrated within the islets [90].…”

Section: Autonomic Nervous Systemmentioning

confidence: 75%

“…The study was performed on 50 pancreatic autopsies of foetuses from the 10th to 40th gestational week (g.w.). Foetal pancreatic autopsies were divided into four groups according to the classifica- and somatostatin) and epithelial cells (cytokeratin 19 (CK19)) were used in this work [89,90]. We generated new data concerning the spatio-temporal distribution of the innervation in the human pancreas during prenatal development.…”

Section: Pancreatic Innervation During Prenatal Developmentmentioning

confidence: 99%

Development of Human Pancreatic Innervation

Proshchina¹,

Krivova²,

Леонова³

et al. 2018

Autonomic Nervous System

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Human pancreatic innervation is of particular interest due to its possible role in the pathogenesis of such diseases as diabetes mellitus, pancreatitis and pancreatic cancer. Despite the clinical importance, data concerning pancreatic innervation during human ontogeny and in various disorders are very limited. In this chapter, we present a review on human pancreatic autonomic innervation on the basis of the literature data and our previous results. Special attention is paid to the innervation of the endocrine pancreas. Gradual branching of neural network was seen during human pancreatic development. Innervation of the foetal pancreas is more abundant than in adults. In agreement with previous observations, we have revealed a close integration and similarity between endocrine cells and nervous elements in the developing human pancreas. Moreover, simultaneous interactions between the nervous system components, epithelial cells and endocrine cells were detected in the pancreas during prenatal human development. It has been suggested that pancreatic innervation plays an important role not only in regulation of endocrine and exocrine activity but also in normal islet morphogenesis.

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“…Most sympathetic nerves innervate smooth muscle cells of the blood vessels in the adult human pancreas. However, the human fetal pancreas is richly innervated (Taborsky, 2011; Krivova et al, 2016). Islet innervation is correlated with age and environmental factors in humans and rats (Proshchina et al, 2014; Mundinger et al, 2016; Tang et al, 2018b).…”

Section: Neural Regulation Of Isletsmentioning

confidence: 99%

“…Islet innervation is correlated with age and environmental factors in humans and rats (Proshchina et al, 2014; Mundinger et al, 2016; Tang et al, 2018b). The integration between epithelial cells and components of the nervous system may form the neuro-insular complexes seen during cellular differentiation (Krivova et al, 2016). In addition, the composition and cytoarchitecture of endocrine cells are also different in humans and rats (Rodriguez-Diaz and Caicedo, 2014; Thorens, 2014; Dolensek et al, 2015; Da Silva Xavier, 2018).…”

Section: Neural Regulation Of Isletsmentioning

confidence: 99%

Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion

Liu

et al. 2019

Front. Neurosci.

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Extrapancreatic nerves project to pancreatic islets directly or converge onto intrapancreatic ganglia. Intrapancreatic ganglia constitute a complex information-processing center that contains various neurotransmitters and forms an endogenous neural network. Both intrapancreatic ganglia and extrapancreatic nerves have an important influence on pancreatic endocrine function. This review introduces the histomorphology, innervation, neurochemistry, and electrophysiological properties of intrapancreatic ganglia/neurons, and summarizes the modulatory effects of intrapancreatic ganglia and extrapancreatic nerves on endocrine function.

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Structure of neuro-endocrine and neuro-epithelial interactions in human foetal pancreas

Cited by 9 publications

References 52 publications

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

Vagal mechanisms as neuromodulatory targets for the treatment of metabolic disease

Development of Human Pancreatic Innervation

Intrapancreatic Ganglia and Neural Regulation of Pancreatic Endocrine Secretion

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