Structure of the Complex of an Iminopyridinedione Protein Tyrosine Phosphatase 4A3 Phosphatase Inhibitor with Human Serum Albumin

Abstract

also known as osteonectin; T max , time required to reach maximum plasma concentration; UNL unknown ligand.

Structural and mechanistic insights into the transport of aristolochic acids and their active metabolites by human serum albumin

“…4 ). Difference in electron density at the outer “lip” of this pocket reflects the presence of AA-II, exhibiting a binding mode that is somewhat reminiscent of diclofenac or JMS-053 interactions with subdomain IB ( 72 , 73 ). While the space between Y138 and Y161 in the HSA MYR /AA-I complex is occupied by an AA ligand that replaces the myristate molecule at FA1, AA-II populates the subdomain IB pocket in what appears to be a secondary binding site ( Fig.…”

Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids

“… 39 Before data collection, the presence of cobalt in the ESA crystal was confirmed by a fluorescence spectrum with the excitation energy at 12 664 eV (0.979 Å) using HKL-3000. 40 In structures of HSA (PDB ID: ) 41 and ESA (PDB ID: ) 35 were used as templates for molecular replacement. Structure determination and refinement were performed using HKL-3000 integrated with MOLREP, 42 REFMAC, 43 Coot, 44 and other programs from the CCP4 package.…”

An Albumin-Binding Domain Peptide Confers Enhanced Immunoprotection Against Viral Myocarditis by CVB3 VP1 Vaccine

“…Later, “albumin hitchhiking” effect was used by more small molecule compounds and peptide drugs to achieve dLNs enrichment ( 16 ). Meanwhile, coupling with long half-life albumins would also obviously increase the in vivo retention periods of oligonucleotides ( 17 ), compounds ( 18 ) or proteins ( 19 ).…”