Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

Kim, J. M.; Brannan, Camilynn I.; Copeland, Neal G.; Jenkins, Nancy A.; Khan, Tehmina Ahsen; Moore, Kevin W.

doi:10.4049/jimmunol.148.11.3618

Cited by 202 publications

(3 citation statements)

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“…Human IL-10 is encoded by the IL-10 gene, located on the long arm of chromosome 1 ( 48 ). The IL-10 gene promoter is characterized by the presence of positive and negative regulatory sequences as well as polymorphisms that can significantly affect IL-10 expression between individuals ( 49 , 50 ).…”

Section: Il-10 Structure and Signaling Pathwaymentioning

confidence: 99%

The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

Carlini,

Noonan,

Abdalalem

et al. 2023

Front. Immunol.

110

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Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions. Given the pivotal role of IL-10 in immune modulation, this cytokine could have relevant implications in pathologies characterized by hyperinflammatory state, such as cancer, or infectious diseases as in the case of COVID-19 and Post-COVID-19 syndrome. Recent evidence proposed IL-10 as a predictor of severity and mortality for patients with acute or post-acute SARS-CoV-2 infection. In this context, IL-10 can act as an endogenous danger signal, released by tissues undergoing damage in an attempt to protect the organism from harmful hyperinflammation. Pharmacological strategies aimed to potentiate or restore IL-10 immunomodulatory action may represent novel promising avenues to counteract cytokine storm arising from hyperinflammation and effectively mitigate severe complications. Natural bioactive compounds, derived from terrestrial or marine photosynthetic organisms and able to increase IL-10 expression, could represent a useful prevention strategy to curb inflammation through IL-10 elevation and will be discussed here. However, the multifaceted nature of IL-10 has to be taken into account in the attempts to modulate its levels.

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Section: Il-10 Structure and Signaling Pathwaymentioning

confidence: 99%

The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

Carlini,

Noonan,

Abdalalem

et al. 2023

Front. Immunol.

110

View full text Add to dashboard Cite

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“…The high frequency expression haplotypes of IL-10 were associated with serum IL-10 in patients with GBS compared to healthy controls (p = 0.008, OR = 11.67, 95% CI = 1.86-128.7, pc = 0.024; Table 5). Patients at nadir with MRC-sumscore < 40 were defined as severely affected patients and with MRC-sumscore ≥ 40-60 were defined as mildly affected patients; ability to walk independently at 6 months of follow-up was classified as good outcome (with GBS-DS of 0, 1, and 2); unable to walk independently (with GBS-DS of 3, 4, and 5) or death (with GBS-DS of 6) as poor outcome 19 ; GCC/GTA, GCC/ATA and GCC/GCA represent high frequency; GCC/GCC, GCC/ACC, GCC/ACA, GCA/GTA, and GCA/GCA represent medium frequency; frequency ≤ 2.6 represent low haplotype combinations; *statistically significant.…”

Section: Distribution Of Il-10 Polymorphisms In Clinical and Serologi...mentioning

confidence: 99%

“…All these effects are considered very important in the pathogenesis of GBS. 18 The IL-10 gene is chromosomally located at 1q31-1q32, 19,20 and the production of this cytokine is strongly influenced by genetic factors. 21 Several polymorphic sites have been described in the promoter region of IL-10 gene including the bi-allelic polymorphisms at -1082 G/A (rs1800896), -819 C/T (rs1800871) and -592 C/A (rs1800872) locus of the gene's transcriptional start site which are most common and important in the pathogenesis of autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

Interleukin‐10 promoter polymorphisms and haplotypes in patients with Guillain–Barré syndrome

Hayat,

Asad,

Munni

et al. 2023

Ann Clin Transl Neurol

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ObjectiveInterleukin‐10 (IL‐10) is a multifunctional cytokine that exerts both pro‐ and anti‐inflammatory effects on the immune system as well as in the pathogenesis of Guillain–Barré syndrome (GBS). We investigated whether the three common polymorphisms ‐1082 G/A(rs1800896), ‐819 C/T(rs1800871), and ‐592 C/A(rs1800872) in the promoter region of IL‐10 have any influence on the susceptibility, severity, and clinical outcome of GBS.MethodsIL‐10 promoter polymorphisms were investigated in 152 patients with GBS and 152 healthy controls from Bangladesh using polymerase chain reaction and restriction fragment length polymorphism (PCR‐RFLP), and allele‐specific oligonucleotide‐PCR (ASO‐PCR). Haplotype patterns and frequencies were analyzed using Heatmaply R‐package, chi‐square, and Fisher's exact test. The serum level of IL‐10 was measured through enzyme‐linked immunosorbent assays. p‐values < 0.05 were considered statistically significant.ResultsIL‐10 promoter polymorphisms ‐1082 G/A, ‐819 C/T, and ‐592 C/A were not associated with GBS susceptibility. The homozygous ‐819 TT genotype showed a tendency with susceptibility (p = 0.029; pc = 0.08) and was prevalent in axonal variants of GBS compared to demyelinating subtypes and controls (p = 0.042, OR = 8.67, 95% CI = 1.03–72.97; pc = 0.123 and p = 0.005, OR = 4.2, 95% CI = 1.55–11.40; pc = 0.015, respectively). Haplotype analysis revealed 19 patterns of genotypes and high IL‐10 expression haplotype combinations (GCC/GTA, GCC/ATA, and GCC/GCA) may have influence on disease severity (p = 0.026; pc = 0.078). Serum expression of IL‐10 was elevated in GBS patients ([GBS, 12.16 ± 45.71] vs. [HC, 0.65 ± 5.17] pg/mL; p = 0.0027) and varied with disease severity ([severe‐GBS, 15.25 ± 51.72] vs. [mild‐GBS, 3.59 ± 19.79] pg/mL, p = 0.046).InterpretationThe ‐819 TT genotypes influence axonal GBS, and high frequency of IL‐10 expression haplotype combination with elevated serum IL‐10 may play an important role in disease severity.

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Interleukin-10 gene promoter polymorphisms in multiple myeloma

et al. 2001

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Multiple myeloma (MM) is a B‐cell malignancy characterized by an accumulation of malignant plasma cells in the bone marrow. It is unclear whether genetic background could have an etiological impact on MM or influence the course of the disease. Interleukin‐10 (IL‐10) has been implicated in the growth and differentiation of normal B cells, and has also been shown to enhance the proliferation of MM cells. To address the putative involvement of IL‐10 genetic variation in MM, we analyzed previously defined loci for bi‐allelic polymorphism at position ‐1082 and two microsatellite loci (IL10.G and IL10.R) in the IL‐10 promoter region. Seventy‐three patients with MM, 27 with monoclonal gammopathy of undetermined significance, and 109 ethnically matched individuals as controls were included in the study. Significantly increased frequencies of the IL10.G genotype 136/136 and the IL10.R genotype 112/114, in addition to a decreased frequency of the IL10.R genotype 114/116, were found among the MM patients. Increased production of IL‐10 was detected in the supernatants of lipopolysaccharide‐stimulated peripheral blood mononuclear cells from MM patients who were homozygotes (136/136) and heterozygotes (136/non‐136) for the IL10.G allele 136, as compared with the other IL10.G genotype carriers (non‐136/non‐136). These results suggest that the genetic variation in the IL‐10 promoter region may play a role in the development of MM. © 2001 Wiley‐Liss, Inc.

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Structure of the mouse IL-10 gene and chromosomal localization of the mouse and human genes.

Cited by 202 publications

References 0 publications

The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

Interleukin‐10 promoter polymorphisms and haplotypes in patients with Guillain–Barré syndrome

Interleukin-10 gene promoter polymorphisms in multiple myeloma

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