Structure of the xanthonolignoid kielcorin

Nielsen, Hanne Mørck; Arends, Peter

doi:10.1016/s0031-9422(00)88766-x

Cited by 43 publications

(19 citation statements)

References 8 publications

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“…They also isolated two other xanthonolignoids named Cadensins A and B from Caraipa densiflora. A xanthonolignoid Kielcorin was obtained from Hypericum species [41]. Recently, kielcorin was also isolated from Vismia guaramirangae [42], Kielmeyera variabilis [43], and Hypericum canariensis [44], whereas cadensin C and cadensin D from Vismia guaramirangae and Hypericum canariensis have been reported [45].…”

Section: Xanthonolignoidsmentioning

confidence: 99%

Naturally Occurring Xanthones: Chemistry and Biology

Negi

Bisht

Singh

et al. 2013

Journal of Applied Chemistry

164

120

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Xanthones are one of the biggest classes of compounds in natural product chemistry. A number of xanthones have been isolated from natural sources of higher plants, fungi, ferns, and lichens. They have gradually risen to great importance because of their medicinal properties. This review focuses on the types, isolation, characterization, biological applications, and biosynthesis of naturally occurring xanthones isolated so far. Different physicochemical and instrumental methods such as liquid-solid and liquid-liquid extraction, TLC, flash chromatography, column chromatography, IR,1H NMR and13C NMR spectroscopy, GLC, HPLC, GC, and LCMS have been widely used for isolation and structural elucidation of xanthones. Hepatoprotective, anticarcinogenic, antileprosy, antimalarial, antioxidant, anticholinergic, mutagenicity, radioprotective, immunomodulatory, antibone resorption, antiparasitic, neuraminidase inhibitory, anticomplement, antibacterial, antifungal, algicidal, anti-HIV, cardioprotective, antitumoral, antidiabetes, antihyperlipidemic, antiatherogenic, anti-inflammatory, antiulcer, antidiabetic, hypolipidemic, analgesic, antiasthmatic, antihistaminic, antiamoebic, diuretic, antidiarrheal, larvicidal, and ovicidal activities have been reported for natural occurring xanthones. To a certain extent, this review provides necessary foundation for further research and development of new medicines.

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Section: Xanthonolignoidsmentioning

confidence: 99%

Naturally Occurring Xanthones: Chemistry and Biology

Negi

Bisht

Singh

et al. 2013

Journal of Applied Chemistry

164

120

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show abstract

“…Other typical constituents are xanthones (1,3,6,7-tetrahydroxyxanthone and kielcorin C (0.01%) (Nielsen and Arends, 1978), acids (isovalerianic, nicotinic, myristic, palmitic, and stearic), carotenoids, choline, nicotinamide, pectin, ␤-sitosterol, pectin, fatty acids, amino acids, vitamin C, tannins (Duke, 1985), hydroperoxycadiforin (in stems and leaves) (Rücker et al, 1995) and bisanthraquinone glycosides (Wirz et al, 2000) (Table 1).…”

Section: Other Chemical Constituentsmentioning

confidence: 99%

A review of the antibacterial activity of Hypericum perforatum L.

Saddiqe

Naeem

Maimoona

2010

Journal of Ethnopharmacology

319

186

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“…The first natural derivative of this Later on, Nielsen and Arends showed that natural kielcorin samples are a mixture of enantiomers of (18B) [88]. They proved by UV spectroscopy that the resultant phenolic compound obtained by basic hydrolysis of the benzylic ether Fig.…”

Section: Xanthonolignoidsmentioning

confidence: 96%

Structure Elucidation of Xanthone Derivatives: Studies of Nuclear Magnetic Resonance Spectroscopy

Silva¹,

Pinto

2005

CMC

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1H and 13C NMR spectra remain the first tool used by chemists to perform the structure elucidation of their products on a routine basis. It is common to provide NMR data on both proton and carbon spectra based on one-dimensional experiments, but often only proton resonances are assigned. The increasing complexity of natural compounds and their synthetic related derivatives imply the use of some more recent 1D and 2D NMR techniques. The purpose of this review is to describe the main NMR features of the most common and important classes of xanthones and also to discuss the application of several 1D and 2D NMR techniques in the structure elucidation of these compounds. A brief discussion of these NMR techniques from the point of view of structure elucidation of organic compounds will also be considered. The calculated NMR chemical shifts in the structure elucidation of xanthones and the use of NMR to study their mode of action in biological activities will be also described.

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Structure of the xanthonolignoid kielcorin

Cited by 43 publications

References 8 publications

Naturally Occurring Xanthones: Chemistry and Biology

Naturally Occurring Xanthones: Chemistry and Biology

A review of the antibacterial activity of Hypericum perforatum L.

Structure Elucidation of Xanthone Derivatives: Studies of Nuclear Magnetic Resonance Spectroscopy

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