Structure–process–property relationship of the polar graphene oxide-mediated cellular response and stimulated growth of osteoblasts on hybrid chitosan network structure nanocomposite scaffolds

Graphene oxide-reinforced biodegradable genipin-cross-linked chitosan fluorescent biocomposite film and its cytocompatibility

“…37 The polar GO has also been found to facilitate the cell attachment and proliferation of osteoblasts on hybrid CS network structures. 16 Here, the in vitro cell culture with the GCS/GO composite sample has also proven nontoxic, which may be attributed to the excellent biocompatibility of GO at low concentration and the hydrophilic property of GO, as well as the biocompatible nature of GCS. Furthermore, biomolecules like enzyme and anticancer drugs can be further conjoined to the GO sheets, making the biocompatible GCS/GO composite a promising platform for biomedical use.…”

“…28 In a similar work, Yang et al found that the incorporation of only 1 wt% GO into CS composites dramatically increased their tensile strength and Young's modulus, by 122% and 64%, respectively and that the glass-transition temperature increased as well. 29 Here and in other excellent studies on CS/GO composites, 16,30 GO was demonstrated to be an efficient nanofiller for CS, and it can be expected that with largely improved mechanical properties, CS may play a more important role as biomaterials. Although the GO-reinforced CS materials synthesized in previous work are claimed to be useful as biomaterials, little work investigating the biodegradability or biocompatibility of GO-incorporated CS composites has been reported.…”

Graphene oxide has a neuroprotective effect against glutamate-induced excitoxicity on B35 neuroblastoma cell line

“…Chitosan, itself, is a [47] used chitosangraphene network structured scaffolds to cultivate MC3T3-E1 mouse pre-osteoblast cell line, and also observed that chitosan-graphene film facilitated cell attachment, proliferation and growth. Zuo et al [48] used three different films, chitosan, GO-chitosan and GO/chitosan mix to investigate the potential application of C3H10T1/2 cells in growth of articular carti- lage.…”

Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

“…Combining the 2D structures of both tectomers and GO is very appealing for a range of applications, in particular for certain bio-applications that require high surface area materials to act as coatings for implants or as scaffold to enhance biocompatibility, mechanical, and other properties. [82][83][84][85] Here we investigate the interactions between the tectomers and GO with the intention of achieving GO-based biocomposites. For this study, we used well-exfoliated and stable GO dispersions in water.…”