Structure, properties and cytostatic activity of tributyltin aminoarylcarboxylates

Pruchnik, Florian P.; Bańbuła, Małgorzata; Ciunik, Zbigniew; Latocha, Małgorzata; Skop, B; Wilczok, Tadeusz

doi:10.1016/s0020-1693(03)00475-4

Cited by 50 publications

(27 citation statements)

References 29 publications

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“…further away than in 5, a result that might be correlated with steric pressure. The structure of the tri-n-butyl analogue is also known [56]. This is a polymeric compound as a result of bidentate, bridging carboxylate ligands leading to a trans-C 3 O 2 donor set for tin and represents one of the two extremes for the overwhelming majority of triorganotin carboxylates, viz.…”

Section: Description Of the X-ray Crystal Structuresmentioning

confidence: 99%

Triphenyltin(IV) benzoates with diazenyl/imino scaffold exhibiting remarkable apoptosis mediated by reactive oxygen species

Baul

Dutta

Duthie

et al. 2017

Journal of Inorganic Biochemistry

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Section: Description Of the X-ray Crystal Structuresmentioning

confidence: 99%

Triphenyltin(IV) benzoates with diazenyl/imino scaffold exhibiting remarkable apoptosis mediated by reactive oxygen species

Baul

Dutta

Duthie

et al. 2017

Journal of Inorganic Biochemistry

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“…Both TBTA and TPhTA are very active against A549 cells. Also in relation to HCV29T human cell line, they are more active than cis-platinum [13,14]. The mechanism of biological activity of organotin compounds is not yet totally clear.…”

Section: Introductionmentioning

confidence: 99%

“…To understand the molecular interaction of TBTA and TPhTA compounds with plasmid DNA, we used a single-molecule florescence technique, timecorrelated single-photon counting fluorescence correlation spectroscopy (TCSPC-FCS). 2 -4}]-TPhTA were prepared in accordance with procedures described in the literature [13,14]. The most probable structure of this compound is as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Lipid and DNA interaction with the triorganotin dimethylaminophenylazobenzoates studied by DSC and spectroscopy methods

Pruchnik

Kral

Hof

2018

J Therm Anal Calorim

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The aim of the study was to investigate and compare the interaction of tributyltin (TBTA) and triphenyltin (TPhTA) 2-[4 (dimethylamino)phenylazo]benzoates complexes with the lipid membrane and plasmid DNA. Both TBTA and TPhTA belong to the group of promising anticancer agents. Differential scanning calorimetry method was employed to examine the heat signal associated with phase transitions of liposomes formed from dipalmitoylphosphatidylcholine (DPPC) or DPPC/cholesterol and modified with TBTA and TPhTA. The investigated compounds influence the thermotropic parameters of the DPPC and DPPC/cholesterol lipid bilayer in a slightly different way: Although the temperature of the main phase transition of the DPPC remains almost unaffected, the addition of TPhTA can abolish sub-and pre-transition when added in sufficiently high concentrations. At the same time, the addition of the TBTA practically does not change the sub-transition and only slightly influences the pre-transition. The effect of organotin compounds on plasmid DNA was investigated using single-molecule florescence technique and time-correlated single-photon counting fluorescence correlation spectroscopy. Influence of TBTA and TPhTA on DNA resulted only in fractional conformation change which did not lead to the tightly packed conformation however, analysis of the diffusion times indicates that TPhTA interacts with DNA in a different mode than TBTA.

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“…Inorganic and organotin compounds have found industrial use as catalysts like in heterogeneous oxidation catalysts based on tin(IV) oxide [1][2] and homogeneous catalysts for industrial organic and polymeric reactions. [3][4] Apart from the well-established uses of tin catalysts in polyurethanes, 5 RTV silicones 6 and esterification reactions, 7 new developments have included their use as anti-tumor drugs, [8][9] ion carriers in electrochemical membrane, 10 in synthetic vitamin E production 11 and in the manufacture of certain novel polymeric materials. 12 A remarkable but little known fact about tin is to save energy and reduce emissions when added to fuel 13 and are effective premixed methane flame inhibitors.…”

Section: Introductionmentioning

confidence: 99%

Dialkyltin(IV)bis(O–tolyl/benzyldithiocarbonate) complexes: Spectroscopic, thermogravemetric, antifungal and crystal analysis of n–Bu2Sn(S2COCH2C6H5)2

Gupta¹,

Kumar²,

Kalgotra³

et al. 2015

ACSi

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Novel compounds of dimethyl-and dibutyltin(IV) with O-tolyl/benzyldithiocarbonatesSn) spectroscopy. The thermal behaviour of the complex 8 has been studied by TGA/DTA analysis. The complex [(n-Bu) 2 Sn(S 2 COCH 2 C 6 H 5 ) 2 ] (8) crystallizes in the monoclinic space group C2/c, in which tin adopts a distorted octahedron or skew trapezoidal bipyramidal geometry accompanied by two n-butyl chains and the two dithiocarbonate ligands coordinated in an anisobidentate fashion. Antifungal activities against fungus Fusarium sp. of these organotin(IV) derivatives exhibited enhanced activity compared to the free ligands.

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Structure, properties and cytostatic activity of tributyltin aminoarylcarboxylates

Cited by 50 publications

References 29 publications

Triphenyltin(IV) benzoates with diazenyl/imino scaffold exhibiting remarkable apoptosis mediated by reactive oxygen species

Triphenyltin(IV) benzoates with diazenyl/imino scaffold exhibiting remarkable apoptosis mediated by reactive oxygen species

Lipid and DNA interaction with the triorganotin dimethylaminophenylazobenzoates studied by DSC and spectroscopy methods

Dialkyltin(IV)bis(O–tolyl/benzyldithiocarbonate) complexes: Spectroscopic, thermogravemetric, antifungal and crystal analysis of n–Bu2Sn(S2COCH2C6H5)2

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