The aim of this study is to develop more understanding about strategies to support teachers' professional development in curriculum innovations, in which pedagogy and content change simultaneously compared to the conventional curriculum. A pre-existing framework, including strategies for professional development, was adapted, implemented, and evaluated from the perspective of teachers' sense-making in teaching context-based science curricula. This framework guides the design of activities that support teachers' development in three new aspects of teaching context-based science units: setting a context in class, performing a new teaching role, and teaching new content. In a case study, six teachers in secondary education participated in a professional development program based on the adapted framework. A qualitative inner-case analysis was conducted to describe teachers' sense-making during the program, in terms of the categories "assimilation," "accommodation," "toleration," and "distantiation." Results showed that teachers participating in the professional development program successfully assimilated and accommodated all three aspects; however, the process of teachers' sense-making of