Structure–property relationship of pH‐sensitive (PCL)₂(PDEA‐b‐PPEGMA)₂ micelles: Experiment and DPD simulation

Abstract

The experiment and dissipative particle dynamics simulation were carried out on four polymers with different block ratios for the investigation of the structure-property relationship of (poly(e-caprolactone) 2 -[poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate)] 2 [(PCL) 2 (PDEA-b-PPEGMA) 2 ] micelles. The miktoarm star polymers assembled into spherical micelles composed of PCL core, pH-sensitive PDEA mesosphere and poly (ethylene glycol) methyl ether methacrylate (PPEGMA) shell. When decreasing pH from 7.4 to 5.0, the hydrodynamic diameter and transmittance of (PCL) 2 (PDEA-b-PPEGMA) 2 micelles increased along with globule-unevenextended conformational transitions, owing to the protonation of tertiary amine groups of DEA at lower pH conditions. Doxorubicin (DOX) was mainly loaded in the pH-sensitive layer, and more DOX were loaded in the core when increasing drug concentrations. The in vitro DOX release from the micelles was significantly accelerated by decreasing pH from 7.4 to 5.0. The results demonstrated that the pH-sensitive micelles could be used as an efficient carrier for hydrophobic anticancer drugs, achieving controlled and sustained drug release.

Investigation of pH-responsive block glycopolymers with different structures for the delivery of doxorubicin

“…This pH-induced micellization/de-micellization behavior was spontaneous and reversible, which has already been investigated in detail, according to Liu's works. [29][30][31][32][33] The transition of DEA covered over the range of pH 6-8 according to the variation of hydrodynamic diameter of assemblies (as shown in Fig. 2) from the DLS in keeping with reported works, 29,30 these copolymers micelles demonstrated a reversible micellization behaviors during the mentioned pH values.…”

“…[29][30][31][32][33] The transition of DEA covered over the range of pH 6-8 according to the variation of hydrodynamic diameter of assemblies (as shown in Fig. 2) from the DLS in keeping with reported works, 29,30 these copolymers micelles demonstrated a reversible micellization behaviors during the mentioned pH values. 34 However, where the PEG-b-P(DEA-co-GAMA) assembled micelles showed wider transition range compared with the other two for the mixed core of DEA and GAMA random segment.…”

Fabrication of PDEAEMA-based pH-responsive mixed micelles for application in controlled doxorubicin release

“…The DOX loading content (LC) and entrapment efficiency (EE) were adopted to evaluate the drug loading efficiency of the micelles, which were dened and calculated using the equations reported by Zhang et al 29,30 DOX-loaded micelles (1 mg) were dissolved in 10 mL DMSO under vigorous vortexing and were determined using a UV-2450 Shimadzu UV-vis spectrophotometer at 480 nm, where a calibration curve was obtained with DOX-DMSO solutions with different DOX concentrations.…”

Amphiphilic β‐cyclodextrin‐based star‐like block copolymer unimolecular micelles for facile in situ preparation of gold nanoparticles

“…Differently, transmission electron microscopy (TEM) measured sizes and morphologies of GNPs here. The detailed information were given in our previous work . Matrix‐assisted laser desorption/ionization time‐of‐flight (MALDI‐TOF) mass spectra were recorded on a Bruker Autoflex III smartbea TOF equipped with a Nd:YAG laser and with 2,5‐dihydroxy benzoic acid (2,5‐DHB) as matrix and sodium iodide as ionizing agent in reflector and linear mode.…”