Structure-property relationships in manganese oxide - mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery

Chen, Yu; Chen, Hangrong; Zhang, Shengjian; Chen, Feng; Sun, Shi‐Kuan; He, Qianjun; Ma, Ming; Wang, Xia; Wu, Huixia; Zhang, Lingxia; Zhang, Linlin; Shi, Jianlin

doi:10.1016/j.biomaterials.2011.11.086

Cited by 139 publications

(114 citation statements)

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“…75 Not only cell entry by different uptake routes but also the escape of cationic particles from the endosomal-lysosomal system could explain the charge-dependent differences in the intracellular localization of anionic PLGA and mesoporous and chitosan particles. 129,130,168 The predictive value of the aforementioned surface charge-dependent cellular studies is currently not clear. For chemicals, a large multicentre evaluation study identified a rather good correlation (R 2 = 0.77) between IC 50 values in cytotoxicity screening assays and human acute poisoning with various chemicals.…”

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confidence: 99%

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

Frőhlich¹

2012

IJN

2,010

1,416

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Many types of nanoparticles (NPs) are tested for use in medical products, particularly in imaging and gene and drug delivery. For these applications, cellular uptake is usually a prerequisite and is governed in addition to size by surface characteristics such as hydrophobicity and charge. Although positive charge appears to improve the efficacy of imaging, gene transfer, and drug delivery, a higher cytotoxicity of such constructs has been reported. This review summarizes findings on the role of surface charge on cytotoxicity in general, action on specific cellular targets, modes of toxic action, cellular uptake, and intracellular localization of NPs. Effects of serum and intercell type differences are addressed. Cationic NPs cause more pronounced disruption of plasma-membrane integrity, stronger mitochondrial and lysosomal damage, and a higher number of autophagosomes than anionic NPs. In general, nonphagocytic cells ingest cationic NPs to a higher extent, but charge density and hydrophobicity are equally important; phagocytic cells preferentially take up anionic NPs. Cells do not use different uptake routes for cationic and anionic NPs, but high uptake rates are usually linked to greater biological effects. The different uptake preferences of phagocytic and nonphagocytic cells for cationic and anionic NPs may influence the efficacy and selectivity of NPs for drug delivery and imaging.

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confidence: 99%

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

Frőhlich¹

2012

IJN

2,010

1,416

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“…[192][193][194][195][196][197][198][199][200][201][202] For instance, MSNs are regarded as one of the most representative inorganic NPs for applications as drug carriers in biomedicine. [ 97,98,115,[202][203][204][205][206][207][208][209][210][211][212][213] In this regard, MONs can be considered as a typical example of organic-inorganic hybrid nanosystems with molecular framework hybridization for nanomedicine.…”

Section: Biomedical Applications Of Monsmentioning

confidence: 99%

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

2016

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Organic-inorganic hybrid materials aiming to combine the individual advantages of organic and inorganic components while overcoming their intrinsic drawbacks have shown great potential for future applications in broad fields. In particular, the integration of functional organic fragments into the framework of mesoporous silica to fabricate mesoporous organosilica materials has attracted great attention in the scientific community for decades. The development of such mesoporous organosilica materials has shifted from bulk materials to nanosized mesoporous organosilica nanoparticles (designated as MONs, in comparison with traditional mesoporous silica nanoparticles (MSNs)) and corresponding applications in nanoscience and nanotechnology. In this comprehensive review, the state-of-art progress of this important hybrid nanomaterial family is summarized, focusing on the structure/composition-performance relationship of MONs of well-defined morphology, nanostructure, and nanoparticulate dimension. The synthetic strategies and the corresponding mechanisms for the design and construction of MONs with varied morphologies, compositions, nanostructures, and functionalities are overviewed initially. Then, the following part specifically concentrates on their broad spectrum of applications in nanotechnology, mainly in nanomedicine, nanocatalysis, and nanofabrication. Finally, some critical issues, presenting challenges and the future development of MONs regarding the rational synthesis and applications in nanotechnology are summarized and discussed. It is highly expected that such a unique molecularly organic-inorganic nanohybrid family will find practical applications in nanotechnology, and promote the advances of this discipline regarding hybrid chemistry and materials.

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“…As we all know, the modified manganese oxide nanomaterials exhibit stupendous potential biological applications for multifunctional imaging and drug delivery [1][2][3][4]. Currently, silica-coated manganese oxide nanoparticles (MnO@SiO 2 NPs) are considered one of the most important materials for MRI contrast agents that can be loaded with drugs, conjugated with fluorescent dyes or targeted molecules [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of mitochondrial-targeting silica-coated manganese oxide nanoparticles

et al. 2015

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The mitochondrion is a promising target for diagnosis and therapy. Mitochondrial-targeting silica-coated manganese oxide nanoparticles (MnO@SiO 2 -PPh 3 + NPs) were successfully synthesized to explore the mitochondrial cytotoxicity of nanoparticles. The mitochondrial targeting property was confirmed by a laser scanning confocal microscopy experiment. Even after incubation for only 4 h, the cytotoxicity of MnO@SiO 2 -PPh 3 + NPs against cancer cells was obvious; the ATP content was significantly decreased to 40%; and the mitochondrial membrane potential was depleted. All of these results indicated the collapse of mitochondrial function and the start of a cell apoptosis pathway. Our findings suggest that mitochondrial-mediated apoptosis could be strengthened by targeting to the subcellular compartment.

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Structure-property relationships in manganese oxide - mesoporous silica nanoparticles used for T1-weighted MRI and simultaneous anti-cancer drug delivery

Cited by 139 publications

References 50 publications

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

Chemistry of Mesoporous Organosilica in Nanotechnology: Molecularly Organic–Inorganic Hybridization into Frameworks

Cytotoxicity of mitochondrial-targeting silica-coated manganese oxide nanoparticles

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