Structure-toxicity relationships for Tetrahymena: Aliphatic aldehydes

Schultz, T.W.; Bryant, S E; Lin, David

doi:10.1007/bf00198500

Cited by 28 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Biological activity is thus dependent on transport to the active site. Similar observations have been reported previously (Deneer et al, 1988;Schultz et al, 1994). Studies using literature toxicity data for aldehydes to ».…”

Section: Discussionsupporting

confidence: 87%

Structure–Toxicity Relationships for Three Mechanisms of Action of Toxicity toVibrio fischeri

Cronin

Schultz

1998

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

Structure–Toxicity Relationships for Three Mechanisms of Action of Toxicity toVibrio fischeri

Cronin

Schultz

1998

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

“…Thus in the modeling of certain bioreactive toxicants, especially within congeneric series, interaction terms are excluded, resulting in high quality, simple log K ow -dependent relationships. This leads to a family of hydrophobicity-dependent linear relationships with different slopes, as evidenced by the results obtained for the proelectrophiles 2-alkyn-1-ols (slope = 0.64; Schultz and Tichy 1993) and aliphatic aldehydes (slope = 0.52; Schultz et al 1994).…”

Section: Resultsmentioning

confidence: 99%

Structure-Toxicity Relationships for Aliphatic Isothiocyanates to Tetrahymena pyriformis

Schultz

Comeaux

1996

Bulletin of Environmental Contamination and Toxicology

View full text Add to dashboard Cite

“…These effects can be added with each other independently to form different linear or non-linear Hansch mod- els [24,25] , which were widely used to establish QSAR models [26,27] .…”

Section: Principles and Methods Of (Q)sarsmentioning

confidence: 99%

Progress and perspectives of quantitative structure-activity relationships used for ecological risk assessment of toxic organic compounds

Chen

et al. 2008

Sci. China Ser. B-Chem.

View full text Add to dashboard Cite

Structure-activity relationship (SAR) and quantitative structure-activity relationship (QSAR), collectively referred to as (Q)SARs, play an important role in ecological risk assessment (ERA) of organic chemicals. (Q)SARs can fill the data gap for physical-chemical, environmental behavioral and ecotoxicological parameters of organic compounds; they can decrease experimental expenses and reduce the extent of experimental testing (especially animal testing); they can also be used to assess the uncertainty of the experimental data. With the development for several decades, (Q)SARs in environmental sciences show three features: application orientation, multidisciplinary integration, and intelligence. Progress of (Q)SAR technology for ERA of toxic organic compounds, including endpoint selection and mathematic methods for establishing simple, transparent, easily interpretable and portable (Q)SAR models, is reviewed. The recent development on defining application domains and diagnosing outliers is summarized. Model characterization with respect to goodness-of-fit, stability and predictive power is specially presented. The purpose of the review is to promote the development of (Q)SARs orientated to ERA of organic chemicals.(Q)SARs, ecological risk assessment, application domain, stability, predictive power

show abstract

Structure-toxicity relationships for Tetrahymena: Aliphatic aldehydes

Cited by 28 publications

References 7 publications

Structure–Toxicity Relationships for Three Mechanisms of Action of Toxicity toVibrio fischeri

Structure–Toxicity Relationships for Three Mechanisms of Action of Toxicity toVibrio fischeri

Structure-Toxicity Relationships for Aliphatic Isothiocyanates to Tetrahymena pyriformis

Progress and perspectives of quantitative structure-activity relationships used for ecological risk assessment of toxic organic compounds

Contact Info

Product

Resources

About