Structured alcohol cessation support program versus current practice in acute alcoholic pancreatitis (PANDA): Study protocol for a multicentre cluster randomised controlled trial

Sissingh, Noor J.; Nagelhout, Anne; Besselink, Marc G.; Boermeester, Marja A.; Bouwense, Stefan A.W.; Bruno, Marco J.; Fockens, Paul; Goudriaan, Anneke E.; Rodríquez-Girondo, Mar D.M.; van Santvoort, Hjalmar C.; Sijbom, Martijn; van Weert, Henk C.P.M.; van Hooft, Jeanin E.; Umans, Devica S.; Verdonk, Robert C.

doi:10.1016/j.pan.2023.10.015

Pancreatology

2023

DOI: 10.1016/j.pan.2023.10.015

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Structured alcohol cessation support program versus current practice in acute alcoholic pancreatitis (PANDA): Study protocol for a multicentre cluster randomised controlled trial

Noor J. Sissingh,

Anne Nagelhout,

Marc G. Besselink

et al.

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2024

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Cited by 2 publications

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Chronic and Idiopathic Pancreatitis—A Personalized Treatment Approach

von Widdern,

Rosendahl,

Ammer‐Herrmenau

2024

UEG Journal

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Chronic pancreatitis is a fibroinflammatory disease of the pancreas with heterogeneous clinical features and a significant socioeconomic burden. Assessing its aetiology and early diagnosis of associated complications remain challenging. Personalized therapy necessitates precise knowledge of the genetic, biological, and clinical differences within a patient population. In this context, the identification of the underlying aetiology represents an essential cornerstone. This review elucidates current standards for identifying underlying aetiologies and the diagnostic work‐up for idiopathic cases. It provides an overview of general therapeutic approaches and highlights individual treatment options. Additionally, the follow‐up management of pancreatitis‐associated complications, namely exocrine pancreatic insufficiency, post‐pancreatitis diabetes mellitus, pain management, pancreatic fluid collections, and pancreatic cancer risk, is summarized.

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Chronic and Idiopathic Pancreatitis—A Personalized Treatment Approach

von Widdern,

Rosendahl,

Ammer‐Herrmenau

2024

UEG Journal

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Gallstones as a cause in presumed acute alcoholic pancreatitis: observational multicentre study

Sissingh,

de Rijk,

Timmerhuis

et al. 2024

British Journal of Surgery

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Background Data on the incidence and clinical relevance of gallstones in patients with suspected acute alcoholic pancreatitis are lacking and are essential to minimize the risk of recurrent acute pancreatitis. The aim of this study was to assess the incidence of gallstones and the associated rate of recurrent acute pancreatitis in patients with presumed acute alcoholic pancreatitis. Methods Between 2008 and 2019, 23 hospitals prospectively enrolled patients with acute pancreatitis. Those diagnosed with their first episode of presumed acute alcoholic pancreatitis were included in this study. The term gallstones was used to describe the presence of cholelithiasis or biliary sludge found during imaging. The primary outcome was pancreatitis recurrence during 3 years of follow-up. Results A total of 334 patients were eligible for inclusion, of whom 316 were included in the follow-up analysis. Gallstone evaluation, either during the index admission or during follow-up, was performed for 306 of 334 patients (91.6%). Gallstones were detected in 54 patients (17.6%), with a median time to detection of 6 (interquartile range 0–42) weeks. During follow-up, recurrent acute pancreatitis occurred in 121 of 316 patients (38.3%), with a significantly higher incidence rate for patients with gallstones compared with patients without gallstones (59% versus 34.2% respectively; P < 0.001), while more patients with gallstones had stopped drinking alcohol at the time of their first recurrence (41% versus 24% respectively; P = 0.020). Cholecystectomy was performed for 19 patients with gallstones (36%). The recurrence rate was lower for patients in the cholecystectomy group compared with patients who did receive inadequate treatment or no treatment (5/19 versus 19/34 respectively; P = 0.038). Conclusion Gallstones were found in almost one in every five patients diagnosed with acute alcoholic pancreatitis. Gallstones were associated with a higher rate of recurrent pancreatitis, while undergoing cholecystectomy was associated with a reduction in this rate.

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Structured alcohol cessation support program versus current practice in acute alcoholic pancreatitis (PANDA): Study protocol for a multicentre cluster randomised controlled trial

Cited by 2 publications

References 46 publications

Chronic and Idiopathic Pancreatitis—A Personalized Treatment Approach

Chronic and Idiopathic Pancreatitis—A Personalized Treatment Approach

Gallstones as a cause in presumed acute alcoholic pancreatitis: observational multicentre study

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