Structures and Absolute Configurations of Antibiotics of the Oligosporon Group from the Nematode-trapping Fungus Arthrobotrys oligospora.

Anderson, Margaret G.; Jarman, T. B.; Rickards, Rodney W.

doi:10.7164/antibiotics.48.391

Cited by 60 publications

(64 citation statements)

References 16 publications

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“…These two compounds were active against the intestinal parasitic nematode Haemonchus contortus with LD 50 values of 25 and 50-100 μg mL -1 . However, they were inactive against the nematode C. elegans at concentrations up to 100 μg mL -1 [83,84].…”

Section: Terpenoidsmentioning

confidence: 98%

Nematicidal Substances from Fungi

Zhang²,

Xu³

et al. 2007

BIOT

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This review summarizes the 179 compounds from fungi that have shown to possess nematicidal activities. These compounds belong to diverse chemical groups and they are mainly isolated from a variety of deuteromycete, ascomycete and basidiomycete fungi. Some of them have been patented as nematicidal agents. We review and classify these compounds based on their structural types. Their nematicidal activities are described and their potential roles in natural environments and in the biocontrol of nematodes are discussed.

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Section: Terpenoidsmentioning

confidence: 98%

Nematicidal Substances from Fungi

Zhang²,

Xu³

et al. 2007

BIOT

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“…We were unable to obtain any oligosporon metabolites with an acetyl group on the cyclohexenol moiety as described in literature. 6,7 Most interestingly, the pair of C-1 epimers, compounds 2 and 3, were obtained from all the A. oligospora strains tested. This result is similar to previous reports that another pair of C-1 epimers, oligosporols B and A, were isolated from strains of A. oligospora from The Netherlands and Australia.…”

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confidence: 99%

Arthrobotrisins A–C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora

et al. 2011

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Arthrobotrys oligospora is a carnivorous fungus that can use mycelia trapping devices to capture their prey. Three novel oligosporons, named arthrobotrisins A-C (1-3), were isolated from A. oligospora and identified by spectroscopic analysis in combination with X-ray diffraction. This is the first time that the relative configuration of naturally occurring oligosporon metabolites has been fully determined. Compound 3 exhibited specific antibacterial activities.

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“…Fungi of Arthrobotrys genus are well‐known for their nematode‐trapping ability and nematocidal activity. Previously, some of oligosporon group antibiotics isolated from Arthrobotrys species were reported to exert moderate nematocidal activity . Currently, there have been no nematocidal agent from this genus of fungi developed yet.…”

Section: Resultsmentioning

confidence: 99%

Epigenetic Manipulation Induces the Production of Coumarin‐Type Secondary Metabolite from Arthrobotrys foliicola

Hsueh

et al. 2019

Israel Journal of Chemistry

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Pursuing epigenetic manipulation approach in fungi led to the isolation of an unusual coumarin metabolite from fungi. An addition of the histone deacetylase inhibitor, suberohydroxamic acid (SBHA), to the culture medium of Arthrobotrys foliicola induced production of the coumarin‐type secondary metabolite represented by a single intensive peak in the HPLC profile of the ethyl acetate extract. The compound which was identified as 4‐ethyl‐7‐hydroxy‐8‐methyl‐2H‐chromen‐2‐one (1) was isolated from nature for the first time. Moreover, the investigation on the remaining part of the HPLC profile led to the separation of 6‐ethyl‐2,4‐dihydroxy‐3‐methylbenzaldehyde (2) and ten 2,5‐diketopiperazine compounds (3–12). The structures of isolates were deduced by their mass and NMR spectroscopic data. The coumarin‐type secondary metabolite (1) with peculiar smell induced by epigenetic stimulation is found for the first time in the Arthrobotrys species and the family Orbiliaceae. We evaluated 1 for the cytotoxic, anti‐inflammatory, anti‐allergic and nematocidal activities, however, it was found inactive.

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Structures and Absolute Configurations of Antibiotics of the Oligosporon Group from the Nematode-trapping Fungus Arthrobotrys oligospora.

Cited by 60 publications

References 16 publications

Nematicidal Substances from Fungi

Nematicidal Substances from Fungi

Arthrobotrisins A–C, Oligosporons from the Nematode-Trapping Fungus Arthrobotrys oligospora

Epigenetic Manipulation Induces the Production of Coumarin‐Type Secondary Metabolite from Arthrobotrys foliicola

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