Structures and biological activities of cycloheptamycins A and B

Qian, Zhengyi; Antosch, Janine; Wiese, Jutta; Imhoff, Johannes F.; Fiedler, Hans‐Peter; Pöthig, Alexander; Gulder, Tobias A. M.

doi:10.1039/c9ob01261c

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2020

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“…is the only example in the literature. 17 Consequently, 1 is unique in containing this rare amino acid.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

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Androsamide, a Cyclic Tetrapeptide from a Marine Nocardiopsis sp., Suppresses Motility of Colorectal Cancer Cells

et al. 2020

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A cyclic tetrapeptide, androsamide (1), was isolated from a marine actinomycete of the genus Nocardiopsis, strain CNT-189. The planar structure of 1 was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of 1 were determined by application of the Marfey’s and advanced Marfey’s methods. Androsamide (1) strongly suppressed the motility of Caco2 cells caused by epithelial–mesenchymal transition.

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“…is the only example in the literature. 17 Consequently, 1 is unique in containing this rare amino acid.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…In the terrestrial environment, the heptadepsipeptide cycloheptamycin A produced by a terrestrial Streptomyces sp. is the only example in the literature . Consequently, 1 is unique in containing this rare amino acid.…”

Section: Resultsmentioning

confidence: 99%