1966
DOI: 10.1038/212311a0
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Structures of the Polymyxins A and the Question of Identity with the Polymyxins M

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Cited by 27 publications
(12 citation statements)
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“…2C). The molecular weight of the polymyxin was the same as those of polymyxins A and M (31,54). The only difference between polymyxin A and M is the D/L configuration of the third amino acid, Dab; a D-Dab is present in polymyxin A, and an L-Dab is found in polymyxin M. From the results of domain analysis, we concluded that the polymyxin produced by P. polymyxa E681 is polymyxin A.…”
Section: Domain Analysis Of the Polymyxin Synthetasementioning
confidence: 62%
“…2C). The molecular weight of the polymyxin was the same as those of polymyxins A and M (31,54). The only difference between polymyxin A and M is the D/L configuration of the third amino acid, Dab; a D-Dab is present in polymyxin A, and an L-Dab is found in polymyxin M. From the results of domain analysis, we concluded that the polymyxin produced by P. polymyxa E681 is polymyxin A.…”
Section: Domain Analysis Of the Polymyxin Synthetasementioning
confidence: 62%
“…The circulins and colistins were originally thought to be quite distinct from the polymyx ins but were later correctly classified as polymyxins (15,16). Octapeptin, also referred to as EM 49 (17), brevistin (18-2 1), stendomycin (22), poly peptin (23), and cerexin (20) have all been isolated andlor characterized within the last seven years.…”
Section: Perspectives and Summarymentioning
confidence: 99%
“…Post 1947, many more peptide antibiotics from various P. polymyxa strains were obtained and classified. These strains were primarily isolated from soil and rhizosphere samples (Wilkinson and Lowe 1966;Kimura et al 1969;Shoji et al 1977a;Pichard et al 1995). Currently, polymyxins derived from Paenibacillus are again attracting an increasing amount of attention for the treatment of multidrugresistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, Klebsiella pneumoniae, and Stenotrophomonas maltophilia (Landman et al 2008;Giamarellou and Poulakou 2009).…”
mentioning
confidence: 99%