Structures of two new diterpenoids from Teucrium polium

Galstyan, Anahit; Шашков, А. С.; Oganesyan, G. B.; Mnatsakanyan, V. A.; Serebryakov, É. P.

doi:10.1007/bf00630646

Cited by 7 publications

(6 citation statements)

References 3 publications

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“…A furan ring is present between C-18 and C-6 in clerodanes 314–316 , 122,123 while plaunol E ( 306 ) has a γ-lactone ring at this same position, as well as a δ-lactol ring between C-20 and C-19. 115 Compound 306 significantly inhibited LPS-induced NO production with an IC 50 value of 2.79 μM.…”

Section: Structure Classifications and Sources Of Clerodane Diterpmentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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The clerodane diterpenoids are a widespread class of secondary metabolites and have been found in several hundreds of plant species from various families and in organisms from other taxonomic groups. These substances have attracted interest in recent years due to their notable biological activities, particularly insect antifeedant properties. In addition, the major active clerodanes of Salvia divinorum can be used as novel opioid receptor probes, allowing greater insight into opioid receptor-mediated phenomena, as well as opening additional areas for chemical investigation. This article provides extensive coverage of naturally occurring clerodane diterpenes discovered from 1990 until 2015, and follows up on the 1992 review by Merritt and Ley in this same journal. The distribution, chemotaxonomic significance, chemical structures, and biological activities of clerodane diterpenes are summarized. In the cases where sufficient information is available, structure activity relationship (SAR) correlations and mode of action of active clerodanes have been presented.

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Section: Structure Classifications and Sources Of Clerodane Diterpmentioning

confidence: 99%

Clerodane diterpenes: sources, structures, and biological activities

2016

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“…Different researchers have suggested that the effects of this plant extract might be due to one or several of its active ingredients such as flavonoid, terpenoid, iridoid, and phenilpropanoid glycosides (23), tannin, saponin, sterol, β-caryophyllene, and diterpenoids (24,25). The ingredients vastly differ based on the meteorological condition, land physical and chemical characteristics, used plant tissues, plant age, developmental phase, and harvesting time.…”

Section: Discussionmentioning

confidence: 99%

Low Dose Teucrium Polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat Aβ25-35 Model of Alzheimer’s Disease

Ghasemi¹,

Sohanaki²,

Keshavarz³

et al. 2019

Arch Neurosci

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Alzheimer's disease (AD) is a multifactorial and debilitating condition without precise etiology and definite cure burdened with high monetary and human resources to the society around the globe. Given that Iranian traditional medicine has a valuable treasure of medicinal plants with multi-dimensional effects, we designed this study to examine one week daily low single-dose treatment protocol of 3 mg/kg Teucrium polium (TP) hydro-alcoholic extract effects on rat's spatial memory performance and CA1 hippocampal neuronal count in rat Aβ25-35 as an AD model. Animals were bilaterally microinjected with single 10 µg/2 µg intrahippocampal Aβ25-35 fragment for the AD induction. After a two-week recovery period, daily intraperitoneal injection of TP for a week was initiated in Aβ-received TP-treated (treated) and TP-received animals (control). Spatial memory performance and CA1 neuronal count were evaluated. TP significantly reduced time latency and distance swum during the first three days of the training protocol compared with Aβ-received rats (sham). Probe reference test findings, however, were not statistically different in treated, sham, and control groups. Intact CA1 hippocampal neuronal count showed a significant increase in Aβ-received TP-treated (case) rats in comparison with Aβ-received (sham) animals. It seems that the least reported low dose TP has the active chemical components capable of memory enhancing effects in Morris water maze (MWM) setting and potential neuronal survival property in hippocampal tissue. In spite of myriad claims against TP use, we should reconsider the matter and do more research to find the exact active ingredients of various species of the plant plus possible underlying mechanisms for ensuring potential use for human clinical trials in AD and other central nervous system-related diseases.

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“…Earlier Galstyan A.M. et al showed that hydroponic Teucrium polium contains flavonoid, terpenoid, iridoid and phenilpropanoid glycosides, exhibiting high biological activity [21, 22]. The expediency of cultivation of Teucrium polium in open hydroponics, in order to obtain the ecologically clean yield and programmed chemical composition-enrichment by flavonoid glycosides (apigenin, luteolin) and phenolic glycosides (verbascoside, poliumoside, teupolioside) was established [23].…”

Section: Discussionmentioning

confidence: 99%

Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats

Simonyan

Chavushyan

2016

BMC Complement Altern Med

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BackgroundThe hippocampus is a target of ovarian hormones, and is necessary for memory. Ovarian hormone loss is associated with a progressive reduction in synaptic strength and dendritic spine. Teucrium polium has beneficial effects on learning and memory. However, it remains unknown whether Teucrium polium ameliorates hippocampal cells spike activity and morphological impairments induced by estrogen deficiency.MethodsIn the present study, we investigated the effects of hydroponic Teucrium polium on hippocampal neuronal activity and morpho-histochemistry of bilateral ovariectomized (OVX) rats. Tetanic potentiation or depression with posttetanic potentiation and depression was recorded extracellularly in response to ipsilateral entorhinal cortex high frequency stimulation. In morpho-histochemical study revealing of the activity of Ca2+-dependent acid phosphatase was observed. In all groups (sham-operated, sham + Teucrium polium, OVX, OVX + Teucrium polium), most recorded hippocampal neurons at HFS of entorhinal cortex showed TD-PTP responses.ResultsAfter 8 weeks in OVX group an anomalous evoked spike activity was detected (a high percentage of typical areactive units). In OVX + Teucrium polium group a synaptic activity was revealed, indicating prevention OVX-induced degenerative alterations: balance of types of responses was close to norm and areactive units were not recorded. All recorded neurons in sham + Teucrium polium group were characterized by the highest mean frequency background and poststimulus activity. In OVX+ Teucrium polium group the hippocampal cells had recovered their size and shape in CA1 and CA3 field compared with OVX group where hippocampal cells were characterized by a sharp drop in phosphatase activity and there was a complete lack of processes reaction.ConclusionThus, Teucrium polium reduced OVX-induce neurodegenerative alterations in entorhinal cortex-hippocamp circuitry and facilitated neuronal survival by modulating activity of neurotransmitters and network plasticity.

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Structures of two new diterpenoids from Teucrium polium

Cited by 7 publications

References 3 publications

Clerodane diterpenes: sources, structures, and biological activities

Clerodane diterpenes: sources, structures, and biological activities

Low Dose Teucrium Polium Hydro-Alcoholic Extract Treatment Effects on Spatial Memory and Hippocampal Neuronal Count of Rat Aβ25-35 Model of Alzheimer’s Disease

Protective effects of hydroponic Teucrium polium on hippocampal neurodegeneration in ovariectomized rats

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