Structures of two new iridoids from linn

Taneja, Subhash C.; Tiwari, H. P.

doi:10.1016/s0040-4039(00)72344-6

Cited by 18 publications

(11 citation statements)

References 3 publications

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“…Plants of genus Barleria are rich sources of iridoids i.e. shanzhiside methyl ester and barlerin (Taneja and Tiwari, 1975;Damtoft et al, 1982;Byrne et al, 1987;Fathalla et al, 2009). Preliminary phytochemical screening of IFBp revealed the abundance of iridoids.…”

Section: Resultsmentioning

confidence: 99%

“…Methanol extract was dried at 50 • C under vaccum, the extractive value (% w/w) was found to be 16.82 of dry weight of plant material. Previous works on BP have led to the isolation and identification of mainly iridoid constituents (Taneja and Tiwari, 1975;Damtoft et al, 1982;Byrne et al, 1987;Chen et al, 1998). Wagner and Bladt (1996) suggested that iridoids can be enriched into n-butanol fraction from the parent extract.…”

Section: Extraction Of Plant Materials and Preparation Of Iridoids Framentioning

confidence: 99%

“…Previous work on the iridoid constituents (monoterpene lactone glucosides) of BP have led to the isolation and identification of shanzhiside methyl ester, 8-O-acetyl shanzhiside methyl ester (barlerin), 6,8-O,O-diacetyl shanzhiside methyl ester (acetylbarlerin) (Taneja and Tiwari, 1975;Damtoft et al, 1982;Byrne et al, 1987;Fathalla et al, 2009) and 6-O-trans-p-coumaryl-8-O-acetyl shanzhiside methyl ester and its cis isomer (Chen et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn

Ghule¹,

Yeole²

2012

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 99%

Section: Extraction Of Plant Materials and Preparation Of Iridoids Framentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn

Ghule¹,

Yeole²

2012

Journal of Ethnopharmacology

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“…Previously published work on the iridoid constituents (monoterpene lactone glucosides) of Barleria species has led to the isolation and identification of SME, 8-O-acetyl shanzhiside methyl ester (barlerin), 6,8-O,O-diacetyl shanzhiside methyl ester (acetylbarlerin) [10][11][12][13], 6-O-trans-p-coumaryl-8-O-acetyl shanzhiside methyl ester, and its cis-isomer [3]. SME is reported from plants of several families [14].…”

Section: Introductionmentioning

confidence: 99%

Validated HPTLC method for simultaneous determination of shanzhiside methyl ester and barlerin inBarleria prionitis

Ghule¹,

Palve²,

Rathi³

et al. 2012

Journal of Planar Chromatography – Modern TLC

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Aerial parts of Barleria prionitis Linn. (Acanthaceae) have shown anti-respiratory syncytial virus, anti-arthritic, anti-inflammatory, hepatoprotective, anti-stress, and immunorestorative activities. The two iridoid glycosides, shanzhiside methyl ester (SME) and barlerin, are the active principles of B. prionitis (BP). For the quality control of BP, rapid methods of quantitation are desirable. Therefore, a simple and reproducible high-performance thin-layer chromatography (HPTLC) method for the simultaneous quantification of SME and barlerin in BP was validated. The marker compounds were isolated, purified, and authenticated by spectral analysis. Precoated silica gel 60 F 254 TLC plates were used as a stationary phase and chloroform-methanol in the proportion of 80:20 (v/v) as the mobile phase. The method was validated in terms of linearity, precision, robustness, accuracy, and limits of detection and quantification. Quantification was performed in the absorbance mode at a wavelength of 240 nm using Deuterium lamp. The linearity was found to be in the range of 200-1000 ng spot -1 for both SME and barlerin, with correlation coefficients of 0.9956 and 0.9932, respectively. The percent recoveries for SME and barlerin were in the range of 99.20 to 99.54%, and 98.93 to 99.19%, respectively. Limits of detection and quantification were found to be 12.95 ng and 21.688 ng, and 17.861 ng and 31.051 ng, respectively, for SME and barlerin. The content (% w/w) of SME and barlerin was found to be 4.91 and 4.69, respectively, in methanol extract of BP. Statistical analysis of the data showed that the proposed method is simple, sensitive, precise, robust and reproducible, specific, and can be employed profitably in place of HPLC.

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“…Kumar et al (2013) (Sawarkar et al, 2009;Nishant et al, 2014). Kumari et al, (2015) Some of the isolated compound from the herbs to name few are, 6-hydroxyflavones, scutellarein-7-rhamnosyl glucoside, barlerin, acetyl barlerin, luteolin-7-O-β-Dglucoside, shanziside methyl ester, 6-O-trans-p-coumaroyl-8-O-acetyl shanziside methyl ester, lupilinoside7-methoxydiderroside, 1,8 dihydroxy-2,7-dimethyl-3,6-dimethoxy anthraquinone,1,3,6,8-tetramethoxy-2,7-dimethyl anthraquinone, prioniside A, prioniside B, prioniside C, balarenone, pipataline (Taneja and Tiwari, 1975;Soren et al, 1982;Gupta and Saxena;1984;Chen et al, 1998;Singh et al, 2005;Ata et al, 2009;Ganga Raju et al, 2002;Ata et al, 2007;Kosmulalage et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial and cytotoxic activities of Barleria prionitis and Barleria grandiflora: A comparative study

Sawarkar¹,

Kashyap²,

Pandey³

et al. 2016

Bangladesh J Pharmacol

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Leaf juices as well as leaves of Barleria prionitis and Barleria grandiflora are being used by rural people across various regions of India in the treatment of oral ailments such as dental troubles, gum ailments, pyorrhoea, dental carries and mouth ulcers. Zone of inhibition and MIC values obtained for all the extracts suggest ethanolic extract of the herbs were more antimicrobial when compared to the aqueous extract. Results of biofilm suppression were found statistically significant (p<0.05) when compared to control. Cytotoxicity was evaluated by MTT assay on human gingival fibroblast and human dermal fibroblast cell lines for ethanolic extract of the herbs. CTC50 value was found to be more than 1,000 µg/mL for ethanolic extracts of both herbs. Chlorhexidine was found to be more cytotoxic with CTC50 value of 12.5–25 µg/mL. Ethanolic extract of B. prionitis and B. grandiflora found significantly cytotoxic (p<0.05) in comparison with control.Video Clip:<a href="https://youtube.com/v/DNByJJQT3RY">Cytotoxicity assay:</a> 18 min 45 sec

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Structures of two new iridoids from linn

Cited by 18 publications

References 3 publications

In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn

In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn

Validated HPTLC method for simultaneous determination of shanzhiside methyl ester and barlerin inBarleria prionitis

Antimicrobial and cytotoxic activities of <i>Barleria prionitis</i> and <i>Barleria grandiflora</i>: A comparative study

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