Structures of virescenosides D and H, new metabolites of Acremonium luzulae(Fuckel) Gams

New Diterpene Glycosides of the Fungus Acremonium striatisporum Isolated from a Sea Cucumber

“…A direct comparison of 1 H and 13 C NMR spectra of 1 with those of the glycosides M and N 1 , and virescenosides A-C, obtained earlier from the terrestrial fungus Acremonium luzulae [2][3][4][5] suggests that virescenoside O has the structure of an isopimaradienic altroside. The 13 [6][7][8][9] Furthermore, the position of the C-17 methyl group (δ 1.09, s) and of the exo-vinyl group at C-13 were argued by 1 H- 13 C HMBC and NOE measurements (Table 1).…”

“…A direct comparison of 1 H and 13 C NMR spectra of 1 with those of the glycosides M and N 1 , and virescenosides A−C, obtained earlier from the terrestrial fungus Acremonium luzulae − suggests that virescenoside O has the structure of an isopimaradienic altroside. The 13 C NMR spectrum of 1 contained signals for a monosubstituted double bond at δ 148.9 (d) and 110.0 (t).…”

New Glycosides of the Fungus Acremonium striatisporum Isolated from a Sea Cucumber

“…The FAB mass spectrum of virescenoside R (1) exhibited a quasimolecular ion peak at m/z 643 [M -H]in the negative ion mode and at m/z 645 [M + H] + and 667 [M + Na] + in the positive ion mode. The molecular formula of 1 was determined as C 32 H 52 O 13 on the basis of a highresolution FABMS (positive ions) peak at m/z 667.3312 (C 32 H 52 O 13 Na requires m/z 667.3306) and was in accordance with 13 C NMR data. Initial examination of the 1-D proton and one-bond 1 H- 13 C correlation NMR data suggested the presence of two sugars (anomeric signals at δ 1 H 5.46 f δ 13 C 99.2 and δ 1 H 5.41 f 100.2).…”

Penicillium and Acremonium

“…Virescenosides A-L (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22) A. luzulae (Cagnoli-Bellavita et al, 1977) OH,CH 2 OH OH CH 2 0H Aphidicolin (23) Aphidicol-16-ene (24) Aphidicol-15-ene (25) Cephalosporium aphidicola…”