Environmental disruptions, such as extreme weather events or poisoning of natural resources, are increasing in frequency and intensity. These critical global problems demand market- and policy-based solutions. Adopting a transformative consumer research perspective, this article examines the effects of environmental disruptions on the livelihoods of a very vulnerable group: nature dependent prosumers (NDPs). NDPs often live in subsistence markets, but the impact of environmental disruptions on their lives can have repercussions throughout local and global systems. This article thus offers practitioners and researchers a framework– the ‘cross-scale intersectionality matrix’ (CSIM)— to better understand the differing impacts of environmental disruptions and envisage effective solutions. The CSIM reveals how environmental disruptions impact marketing systems’ exchanges of production and consumption: i) across multiple spatiotemporal scales, resulting in cross-scale impacts (per eco-systems theory); and ii) in diverse ways for groups/individuals experiencing intersectional power asymmetries such as geo-political/economic power, classism/ableism and sexism (per intersectionality theory). Building on insights from the CSIM framework, this paper proposes improvements to research, and policy and market-based solutions intended to enhance the well-being of NDPs.