Mechanochemistry emerged as an effective tool for the synthesis of nanomaterials, with potentially scalable prospects. This contribution aims to provide an overview of the most recent potential of mechanochemical routes in designing advanced nanomaterials including zeolites, metal oxides, and mixed metal oxides because of their catalytic applications. In the present review, the role of mechanochemistry in material design, the effect of mechanical energy on the surface area/surface properties, and recent trends in the field are discussed. A comparison of catalytic activities in selected cases for the materials prepared using conventional vs mechanochemical route has been provided.