This paper aims to position students' classroom questioning within the literature surrounding affect and its impact on learning. The paper consists of two main sections. First, the act of questioning is discussed in order to highlight how affect shapes the process of questioning, and we describe a four-part genesis to question-asking that we call CARE: the construction, asking, reception and evaluation of a learner's question. This work is contextualised through studies in science education and through our work with university students in undergraduate chemistry, although conducted in the firm belief that it has more general application. The second section of this paper focuses on seven teaching strategies to encourage, ´scaffold´ and manage learner's questions, based here upon the conviction that university students, in this case, learn through questioning, and that an inquiry-based environment promotes better learning than a simple 'transmission' setting.