Understanding students' and teachers' perceptions of using educational games in the science classroom is necessary for the implementation and adoptions of game-based teaching. The current study reviews literature on the status quos of students' and teachers' perceptions of game-based science teaching and explores possible influencing factors of such perceptions. Search terms and screening identified 17 peer-reviewed articles. Results indicate that perception of game-based teaching is generally defined as perceived expectancy and value of using video games in teaching or learning. The findings suggest that most students and teachers hold positive attitudes towards game-based teaching due to its cognitive and emotional effects on learning. However, some teachers only see games as motivation tools and are not confident in integrating games into the classroom due to the lack of relevant skills and extensive technology supports. Students' perceptions may vary across genders and disability statuses. Teachers' game-based teaching experience, educational levels, and professional development programs could influence their perceptions.